Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis
Background. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polym...
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| description | Background. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out. Results. In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis. The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR=1.575, 95%CI=1.259–1.972, P |
| doi_str_mv | 10.1155/2020/5190587 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7273398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A635579866</galeid><sourcerecordid>A635579866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-887e90bc4ecf31b69768efa30760a26e31de5a2c647a2cc405619d4c9efaf9233</originalsourceid><addsrcrecordid>eNqN0U9v0zAcBuAIgdg0duOMLHFBglD_ie2YA1I0sYK0atOAs-U6v6weSdzZ7qp--7lr6YATPsRW8vh1rLcoXhP8kRDOJxRTPOFEYV7LZ8UxZaQqBanI88OasaPiNMZbnEdNBFbiZXHEKFeCUXxcpCZGb51Jzo9oDmkNMKK0ADSbXZWkzBskItMJnaIr328GH5YLFwdkxhZdxgTehLQILrmIrl389Qk16Psmvx9yoEXXcO9g_YhnkEzZjKbfRBdfFS8600c43c8nxc_zLz_OvpYXl9NvZ81FaSulUlnXEhSe2wpsx8hcKClq6AzDUmBDBTDSAjfUikrmp60wF0S1lVUZdYoydlJ83uUuV_MBWgtjCqbXy-AGEzbaG6f__jK6hb7x91pSyZiqc8C7fUDwdyuISQ8uWuh7M4JfRU0rUmdLpcz07T_01q9CvvCjwljhbJ_UjelBu7Hz-Vy7DdWNYJxLVQuR1YedssHHGKA7_DLBetu73vau971n_ubPax7w75YzeL8DCze2Zu3-My63mM82T5qwigvMHgDPSryT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2410090418</pqid></control><display><type>article</type><title>Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Jiankun ; Peng, Zhan ; Wang, Guangye</creator><contributor>Cucchiarini, Magali ; Magali Cucchiarini</contributor><creatorcontrib>Liu, Jiankun ; Peng, Zhan ; Wang, Guangye ; Cucchiarini, Magali ; Magali Cucchiarini</creatorcontrib><description>Background. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out. Results. In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis. The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR=1.575, 95%CI=1.259–1.972, P<0.01; recessive: 2G2G vs. 1G1G+1G2G: OR=2.411, 95%CI=1.658–3.504, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.313, 95%CI=1.341, 3.991, P=0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs. 1G: OR=1.635, 95%CI=1.354, 1.974, P<0.01; dominant: 2G1G+2G2G vs. 1G1G: OR=1.622, 95%CI=1.158, 2.271, P=0.005; recessive: 2G2G vs. 1G1G+1G2G: OR=2.209, 95%CI=1.718, 2.840, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.578, 95%CI=1.798, 3.696, P<0.01), the larger subgroup (N>300), and the hospital-based case-control study (HCC) subgroup. The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable. Begg’s funnel plot and Egger’s test indicated that there was no publication bias in this study. Conclusion. Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/5190587</identifier><identifier>PMID: 32596320</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Arthritis ; Biomedical materials ; Biomedical research ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Correlation analysis ; Degeneration ; Development and progression ; Ethnicity ; Etiology ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic factors ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype & phenotype ; Humans ; Interstitial collagenase ; Matrix metalloproteinase ; Matrix Metalloproteinase 1 - genetics ; Matrix metalloproteinases ; Medical research ; Medicine, Experimental ; Meta-analysis ; Metalloproteinase ; Osteoarthritis ; Osteoarthritis - epidemiology ; Osteoarthritis - genetics ; Pathogenesis ; Polymorphism ; Polymorphism, Single Nucleotide ; Quality ; Researchers ; Review ; Risk Factors ; Sensitivity analysis ; Studies ; Subgroups ; Surgery ; Temporomandibular joint</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-15</ispartof><rights>Copyright © 2020 Jiankun Liu et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Jiankun Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Jiankun Liu et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-887e90bc4ecf31b69768efa30760a26e31de5a2c647a2cc405619d4c9efaf9233</citedby><cites>FETCH-LOGICAL-c499t-887e90bc4ecf31b69768efa30760a26e31de5a2c647a2cc405619d4c9efaf9233</cites><orcidid>0000-0001-5869-4285</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273398/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273398/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4014,27914,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32596320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cucchiarini, Magali</contributor><contributor>Magali Cucchiarini</contributor><creatorcontrib>Liu, Jiankun</creatorcontrib><creatorcontrib>Peng, Zhan</creatorcontrib><creatorcontrib>Wang, Guangye</creatorcontrib><title>Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out. Results. In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis. The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR=1.575, 95%CI=1.259–1.972, P<0.01; recessive: 2G2G vs. 1G1G+1G2G: OR=2.411, 95%CI=1.658–3.504, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.313, 95%CI=1.341, 3.991, P=0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs. 1G: OR=1.635, 95%CI=1.354, 1.974, P<0.01; dominant: 2G1G+2G2G vs. 1G1G: OR=1.622, 95%CI=1.158, 2.271, P=0.005; recessive: 2G2G vs. 1G1G+1G2G: OR=2.209, 95%CI=1.718, 2.840, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.578, 95%CI=1.798, 3.696, P<0.01), the larger subgroup (N>300), and the hospital-based case-control study (HCC) subgroup. The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable. Begg’s funnel plot and Egger’s test indicated that there was no publication bias in this study. Conclusion. Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.</description><subject>Age</subject><subject>Arthritis</subject><subject>Biomedical materials</subject><subject>Biomedical research</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Correlation analysis</subject><subject>Degeneration</subject><subject>Development and progression</subject><subject>Ethnicity</subject><subject>Etiology</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Interstitial collagenase</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix metalloproteinases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Metalloproteinase</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - epidemiology</subject><subject>Osteoarthritis - genetics</subject><subject>Pathogenesis</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quality</subject><subject>Researchers</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Temporomandibular joint</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0U9v0zAcBuAIgdg0duOMLHFBglD_ie2YA1I0sYK0atOAs-U6v6weSdzZ7qp--7lr6YATPsRW8vh1rLcoXhP8kRDOJxRTPOFEYV7LZ8UxZaQqBanI88OasaPiNMZbnEdNBFbiZXHEKFeCUXxcpCZGb51Jzo9oDmkNMKK0ADSbXZWkzBskItMJnaIr328GH5YLFwdkxhZdxgTehLQILrmIrl389Qk16Psmvx9yoEXXcO9g_YhnkEzZjKbfRBdfFS8600c43c8nxc_zLz_OvpYXl9NvZ81FaSulUlnXEhSe2wpsx8hcKClq6AzDUmBDBTDSAjfUikrmp60wF0S1lVUZdYoydlJ83uUuV_MBWgtjCqbXy-AGEzbaG6f__jK6hb7x91pSyZiqc8C7fUDwdyuISQ8uWuh7M4JfRU0rUmdLpcz07T_01q9CvvCjwljhbJ_UjelBu7Hz-Vy7DdWNYJxLVQuR1YedssHHGKA7_DLBetu73vau971n_ubPax7w75YzeL8DCze2Zu3-My63mM82T5qwigvMHgDPSryT</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Liu, Jiankun</creator><creator>Peng, Zhan</creator><creator>Wang, Guangye</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5869-4285</orcidid></search><sort><creationdate>2020</creationdate><title>Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis</title><author>Liu, Jiankun ; Peng, Zhan ; Wang, Guangye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-887e90bc4ecf31b69768efa30760a26e31de5a2c647a2cc405619d4c9efaf9233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Arthritis</topic><topic>Biomedical materials</topic><topic>Biomedical research</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage diseases</topic><topic>Correlation analysis</topic><topic>Degeneration</topic><topic>Development and progression</topic><topic>Ethnicity</topic><topic>Etiology</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic factors</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Interstitial collagenase</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix metalloproteinases</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Metalloproteinase</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - epidemiology</topic><topic>Osteoarthritis - genetics</topic><topic>Pathogenesis</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quality</topic><topic>Researchers</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Surgery</topic><topic>Temporomandibular joint</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jiankun</creatorcontrib><creatorcontrib>Peng, Zhan</creatorcontrib><creatorcontrib>Wang, Guangye</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jiankun</au><au>Peng, Zhan</au><au>Wang, Guangye</au><au>Cucchiarini, Magali</au><au>Magali Cucchiarini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out. Results. In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis. The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR=1.575, 95%CI=1.259–1.972, P<0.01; recessive: 2G2G vs. 1G1G+1G2G: OR=2.411, 95%CI=1.658–3.504, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.313, 95%CI=1.341, 3.991, P=0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs. 1G: OR=1.635, 95%CI=1.354, 1.974, P<0.01; dominant: 2G1G+2G2G vs. 1G1G: OR=1.622, 95%CI=1.158, 2.271, P=0.005; recessive: 2G2G vs. 1G1G+1G2G: OR=2.209, 95%CI=1.718, 2.840, P<0.01; and homozygote: 2G2G vs. 1G1G: OR=2.578, 95%CI=1.798, 3.696, P<0.01), the larger subgroup (N>300), and the hospital-based case-control study (HCC) subgroup. The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable. Begg’s funnel plot and Egger’s test indicated that there was no publication bias in this study. Conclusion. Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32596320</pmid><doi>10.1155/2020/5190587</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5869-4285</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Arthritis Biomedical materials Biomedical research Cartilage Cartilage (articular) Cartilage diseases Correlation analysis Degeneration Development and progression Ethnicity Etiology Gene polymorphism Genes Genetic aspects Genetic factors Genetic polymorphisms Genetic Predisposition to Disease Genotype & phenotype Humans Interstitial collagenase Matrix metalloproteinase Matrix Metalloproteinase 1 - genetics Matrix metalloproteinases Medical research Medicine, Experimental Meta-analysis Metalloproteinase Osteoarthritis Osteoarthritis - epidemiology Osteoarthritis - genetics Pathogenesis Polymorphism Polymorphism, Single Nucleotide Quality Researchers Review Risk Factors Sensitivity analysis Studies Subgroups Surgery Temporomandibular joint |
| title | Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T02%3A04%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20the%20MMP-1-1607%201G/2G%20Polymorphism%20and%20Osteoarthritis%20Risk:%20A%20Systematic%20Review%20and%20Meta-Analysis&rft.jtitle=BioMed%20research%20international&rft.au=Liu,%20Jiankun&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=15&rft.pages=1-15&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2020/5190587&rft_dat=%3Cgale_pubme%3EA635579866%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2410090418&rft_id=info:pmid/32596320&rft_galeid=A635579866&rfr_iscdi=true |