ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer

Alterations in DNA damage response (DDR) genes are common in advanced prostate tumors and are associated with unique genomic and clinical features. ATM is a DDR kinase that has a central role in coordinating DNA repair and cell-cycle response following DNA damage, and alterations are present in appr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2020-06, Vol.80 (11), p.2094-2100
Hauptverfasser:	Rafiei, Shahrzad, Fitzpatrick, Kenyon, Liu, David, Cai, Mu-Yan, Elmarakeby, Haitham A, Park, Jihye, Ricker, Cora, Kochupurakkal, Bose S, Choudhury, Atish D, Hahn, William C, Balk, Steven P, Hwang, Justin H, Van Allen, Eliezer M, Mouw, Kent W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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