Placensin is a glucogenic hormone secreted by human placenta

FBN1 encodes asprosin, a glucogenic hormone, following furin cleavage of the C‐terminus of profibrillin 1. Based on evolutionary conservation between FBN1 and FBN2, together with conserved furin cleavage sites, we identified a peptide hormone placensin encoded by FBN2 based on its high expression in...

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Veröffentlicht in:	EMBO reports 2020-06, Vol.21 (6), p.e49530-n/a
Hauptverfasser:	Yu, Yiping, He, Jia‐Huan, Hu, Lin‐Li, Jiang, Lin‐Lin, Fang, Lanlan, Yao, Gui‐Dong, Wang, Si‐Jia, Yang, Qingling, Guo, Yanjie, Liu, Lin, Shang, Trisha, Sato, Yorino, Kawamura, Kazuhiro, Hsueh, Aaron JW, Sun, Ying‐Pu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cleavage Cyclic AMP Diabetes mellitus EMBO21 Evolutionary conservation Female Fibrillin-1 Furin Gelatinase B Gestational diabetes Gluconeogenesis Glucose Hepatocytes hormone Hormones Humans Invasiveness Kinases Liver Matrix Metalloproteinase 9 Mice Microfilament Proteins Peptide Fragments Peptide Hormones Perfusion placensin Placenta Pregnancy Protein kinase A Secretion Trophoblasts
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