Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

Conformational changes in α‐synuclein (α‐syn) are central to its biological function and Parkinson's disease pathology. Here, terminal alkynes (homopropargylglycine) were employed as environmentally sensitive Raman probes at residues 1, 5, 116, and 127 to characterize soluble (disordered), mice...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2020-06, Vol.21 (11), p.1582-1586
Hauptverfasser:	Flynn, Jessica D., Gimmen, Megan Y., Dean, Dexter N., Lacy, Shannon M., Lee, Jennifer C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Amino acids amyloids C-terminal truncations Dopamine receptors Fibrils Heterogeneity homopropargylglycine Lipids Micelles Movement disorders Neurodegenerative diseases Parkinson's disease Probes Raman spectroscopy Residues Synuclein
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