Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy

Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic ta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2020-03, Vol.130 (3), p.1506-1512
Hauptverfasser:	Sullivan, Jeremy M, Motley, William W, Johnson, Janel O, Aisenberg, William H, Marshall, Katherine L, Barwick, Katy Es, Kong, Lingling, Huh, Jennifer S, Saavedra-Rivera, Pamela C, McEntagart, Meriel M, Marion, Marie-Helene, Hicklin, Lucy A, Modarres, Hamid, Baple, Emma L, Farah, Mohamed H, Zuberi, Aamir R, Lutz, Cathleen M, Gaudet, Rachelle, Traynor, Bryan J, Crosby, Andrew H, Sumner, Charlotte J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Biomedical research Cell surface Charcot-Marie-Tooth disease Charcot-Marie-Tooth Disease - genetics Charcot-Marie-Tooth Disease - metabolism Concise Communication Disease Diseases Drug development Embryos Families & family life Female Genes Genes, Dominant Glycosylation Haplotypes Health aspects Homeostasis Humans Jagged-1 Protein - genetics Jagged-1 Protein - metabolism Jagged1 protein Lethality Ligands Localization Male Medical schools Mice Mutants Mutation Mutation, Missense Ostomy Paralysis Paresis Peripheral nerves Peripheral neuropathy Plasma Post-translational modifications Proteins Receptors, Notch - genetics Receptors, Notch - metabolism Signal transduction Signal Transduction - genetics Therapeutic applications Therapeutics Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!