Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63

Abstract Unrepaired DNA damage in mouse oocytes leads to apoptosis, in part via CHK2 signaling to TRP53 and TRP63. Here, Rinaldi, Bloom, and Schimenti provide evidence that CHK1 can also be involved, especially... Eukaryotic organisms have evolved mechanisms to prevent the accumulation of cells bear...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genetics (Austin) 2020-06, Vol.215 (2), p.373-378
Hauptverfasser:	Rinaldi, Vera D, Bloom, Jordana C, Schimenti, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis ATPases Associated with Diverse Cellular Activities - physiology Cell Cycle Proteins - physiology Checkpoint Kinase 1 - genetics Checkpoint Kinase 1 - metabolism Checkpoint Kinase 2 - genetics Checkpoint Kinase 2 - metabolism CHK1 protein CHK2 protein Chromosome Pairing Chromosomes Damage Deoxyribonucleic acid DNA DNA Damage Endodeoxyribonucleases - physiology Fecundity Female Gametocytes Genetics Homology Hypotheses Investigations Kinases Male Meiosis Mice Mice, Knockout Mutation Oocytes Oocytes - cytology Oocytes - physiology Ovaries p53 Protein Phosphorylation Progeny Prophase Proteins Recombination Signal Transduction Signaling Trans-Activators - genetics Trans-Activators - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Yeast
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!