Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly
Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal sub...
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| Veröffentlicht in: | Human brain mapping 2020-06, Vol.41 (8), p.2037-2047 |
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| creator | Zhang, Liwen Mak, Elijah Reilhac, Anthonin Shim, Hee Y. Ng, Kwun K. Ong, Marcus Q. W. Ji, Fang Chong, Eddie J. Y. Xu, Xin Wong, Zi X. Stephenson, Mary C. Venketasubramanian, Narayanaswamy Tan, Boon Y. O'Brien, John T. Zhou, Juan H. Chen, Christopher L.H. |
| description | Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET‐Aβ in AD‐vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto‐segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ‐related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher Aβ correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal‐to‐widespread trajectory of Aβ‐associated hippocampal subfield atrophy over disease progression in nondemented elderly. |
| doi_str_mv | 10.1002/hbm.24928 |
| format | Article |
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W. ; Ji, Fang ; Chong, Eddie J. Y. ; Xu, Xin ; Wong, Zi X. ; Stephenson, Mary C. ; Venketasubramanian, Narayanaswamy ; Tan, Boon Y. ; O'Brien, John T. ; Zhou, Juan H. ; Chen, Christopher L.H.</creator><creatorcontrib>Zhang, Liwen ; Mak, Elijah ; Reilhac, Anthonin ; Shim, Hee Y. ; Ng, Kwun K. ; Ong, Marcus Q. W. ; Ji, Fang ; Chong, Eddie J. Y. ; Xu, Xin ; Wong, Zi X. ; Stephenson, Mary C. ; Venketasubramanian, Narayanaswamy ; Tan, Boon Y. ; O'Brien, John T. ; Zhou, Juan H. ; Chen, Christopher L.H. ; Alzheimer's Disease Neuroimaging Initiative ; the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><description>Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET‐Aβ in AD‐vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto‐segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ‐related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher Aβ correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal‐to‐widespread trajectory of Aβ‐associated hippocampal subfield atrophy over disease progression in nondemented elderly.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.24928</identifier><identifier>PMID: 31944479</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Alzheimer's disease ; Amyloid ; Atrophy ; Cognitive ability ; Correlation ; Dementia disorders ; Geriatrics ; hippocampal subfield atrophy ; Hippocampus ; Impairment ; longitudinal atrophy trajectory ; Memory ; Neurodegenerative diseases ; nondemented elderly ; Older people ; Segmentation ; β‐Amyloid</subject><ispartof>Human brain mapping, 2020-06, Vol.41 (8), p.2037-2047</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). 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W.</creatorcontrib><creatorcontrib>Ji, Fang</creatorcontrib><creatorcontrib>Chong, Eddie J. Y.</creatorcontrib><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Wong, Zi X.</creatorcontrib><creatorcontrib>Stephenson, Mary C.</creatorcontrib><creatorcontrib>Venketasubramanian, Narayanaswamy</creatorcontrib><creatorcontrib>Tan, Boon Y.</creatorcontrib><creatorcontrib>O'Brien, John T.</creatorcontrib><creatorcontrib>Zhou, Juan H.</creatorcontrib><creatorcontrib>Chen, Christopher L.H.</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><title>Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly</title><title>Human brain mapping</title><addtitle>Hum Brain Mapp</addtitle><description>Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET‐Aβ in AD‐vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto‐segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ‐related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher Aβ correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal‐to‐widespread trajectory of Aβ‐associated hippocampal subfield atrophy over disease progression in nondemented elderly.</description><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Atrophy</subject><subject>Cognitive ability</subject><subject>Correlation</subject><subject>Dementia disorders</subject><subject>Geriatrics</subject><subject>hippocampal subfield atrophy</subject><subject>Hippocampus</subject><subject>Impairment</subject><subject>longitudinal atrophy trajectory</subject><subject>Memory</subject><subject>Neurodegenerative diseases</subject><subject>nondemented elderly</subject><subject>Older people</subject><subject>Segmentation</subject><subject>β‐Amyloid</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kU1u1TAURi1ERUthwAZQJCYwSOu_xPEEqVRAkV7FBMbGdm76_OTEwU5AmXUJXSMrweGVqlRiZEv3-PjT_RB6QfAJwZiebk1_QrmkzSN0RLAUJSaSPV7vdVVKLsgheprSDmNCKkyeoENGJOdcyCP0bROGKzfNrRu0L6aod2CnEJcidMVZv_jg2l_XNxG8nqAttm4cg9X9mNk0m86Bbws9xTBul8INxRCGFnoYVjaPIPrlGTrotE_w_PY8Rl8_vP9yflFuPn_8dH62KS3nrCkl7qiQllHeSGZM21QSsOwMNS01tTZM44bXUta6AqjruqryO4sJFQ3utLbsGL3de8fZ9NDaHCJqr8boeh0XFbRT_04Gt1VX4YcStBb5zyx4fSuI4fsMaVK9Sxa81wOEOSnKmBSSZDyjrx6guzDHvMCVkoJhXlWr8M2esjGkFKG7C0OwWntTuTf1p7fMvryf_o78W1QGTvfAT-dh-b9JXby73Ct_A0A6pN8</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Zhang, Liwen</creator><creator>Mak, Elijah</creator><creator>Reilhac, Anthonin</creator><creator>Shim, Hee Y.</creator><creator>Ng, Kwun K.</creator><creator>Ong, Marcus Q. W.</creator><creator>Ji, Fang</creator><creator>Chong, Eddie J. Y.</creator><creator>Xu, Xin</creator><creator>Wong, Zi X.</creator><creator>Stephenson, Mary C.</creator><creator>Venketasubramanian, Narayanaswamy</creator><creator>Tan, Boon Y.</creator><creator>O'Brien, John T.</creator><creator>Zhou, Juan H.</creator><creator>Chen, Christopher L.H.</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0180-8648</orcidid></search><sort><creationdate>20200601</creationdate><title>Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly</title><author>Zhang, Liwen ; Mak, Elijah ; Reilhac, Anthonin ; Shim, Hee Y. ; Ng, Kwun K. ; Ong, Marcus Q. W. ; Ji, Fang ; Chong, Eddie J. Y. ; Xu, Xin ; Wong, Zi X. ; Stephenson, Mary C. ; Venketasubramanian, Narayanaswamy ; Tan, Boon Y. ; O'Brien, John T. ; Zhou, Juan H. ; Chen, Christopher L.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-90f279c324893bbd859e09fb2bd2b6ab3a0846996a5ee66655c44c012780faac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Atrophy</topic><topic>Cognitive ability</topic><topic>Correlation</topic><topic>Dementia disorders</topic><topic>Geriatrics</topic><topic>hippocampal subfield atrophy</topic><topic>Hippocampus</topic><topic>Impairment</topic><topic>longitudinal atrophy trajectory</topic><topic>Memory</topic><topic>Neurodegenerative diseases</topic><topic>nondemented elderly</topic><topic>Older people</topic><topic>Segmentation</topic><topic>β‐Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Liwen</creatorcontrib><creatorcontrib>Mak, Elijah</creatorcontrib><creatorcontrib>Reilhac, Anthonin</creatorcontrib><creatorcontrib>Shim, Hee Y.</creatorcontrib><creatorcontrib>Ng, Kwun K.</creatorcontrib><creatorcontrib>Ong, Marcus Q. 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Y.</creatorcontrib><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Wong, Zi X.</creatorcontrib><creatorcontrib>Stephenson, Mary C.</creatorcontrib><creatorcontrib>Venketasubramanian, Narayanaswamy</creatorcontrib><creatorcontrib>Tan, Boon Y.</creatorcontrib><creatorcontrib>O'Brien, John T.</creatorcontrib><creatorcontrib>Zhou, Juan H.</creatorcontrib><creatorcontrib>Chen, Christopher L.H.</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Liwen</au><au>Mak, Elijah</au><au>Reilhac, Anthonin</au><au>Shim, Hee Y.</au><au>Ng, Kwun K.</au><au>Ong, Marcus Q. W.</au><au>Ji, Fang</au><au>Chong, Eddie J. Y.</au><au>Xu, Xin</au><au>Wong, Zi X.</au><au>Stephenson, Mary C.</au><au>Venketasubramanian, Narayanaswamy</au><au>Tan, Boon Y.</au><au>O'Brien, John T.</au><au>Zhou, Juan H.</au><au>Chen, Christopher L.H.</au><aucorp>Alzheimer's Disease Neuroimaging Initiative</aucorp><aucorp>the Alzheimer's Disease Neuroimaging Initiative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum Brain Mapp</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>41</volume><issue>8</issue><spage>2037</spage><epage>2047</epage><pages>2037-2047</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET‐Aβ in AD‐vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto‐segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ‐related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher Aβ correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal‐to‐widespread trajectory of Aβ‐associated hippocampal subfield atrophy over disease progression in nondemented elderly.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31944479</pmid><doi>10.1002/hbm.24928</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0180-8648</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alzheimer's disease Amyloid Atrophy Cognitive ability Correlation Dementia disorders Geriatrics hippocampal subfield atrophy Hippocampus Impairment longitudinal atrophy trajectory Memory Neurodegenerative diseases nondemented elderly Older people Segmentation β‐Amyloid |
| title | Longitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly |
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