Bone marrow niche-derived extracellular matrix-degrading enzymes influence the progression of B-cell acute lymphoblastic leukemia

Specific and reciprocal interactions with the bone marrow microenvironment (BMM) govern the course of hematological malignancies. Matrix metalloproteinase-9 (MMP-9), secreted by leukemia cells, facilitates tumor progression via remodeling of the extracellular matrix (ECM) of the BMM. Hypothesizing t...

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Veröffentlicht in:	Leukemia 2020-06, Vol.34 (6), p.1540-1552
Hauptverfasser:	Verma, Divij, Zanetti, Costanza, Godavarthy, Parimala Sonika, Kumar, Rahul, Minciacchi, Valentina R., Pfeiffer, Jakob, Metzler, Markus, Lefort, Sylvain, Maguer-Satta, Véronique, Nicolini, Franck E., Burroni, Barbara, Fontenay, Michaela, Krause, Daniela S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/51 59 631/67/327 64/60 692/308/2778 82 96 96/21 96/31 96/63 Acute lymphoblastic leukemia Acute lymphocytic leukemia Animals B cells Bone marrow Bone Marrow - enzymology Bone Marrow - pathology Bone matrix Cancer Research Comparative analysis Critical Care Medicine Degradation Development and progression Disease Progression Enzymes Extracellular matrix Extracellular Matrix - enzymology Extracellular Matrix - pathology Gelatinase B Hematology Intensive Internal Medicine Leukemia Life Sciences Lymphatic leukemia Lymphocytes B Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Medicine Medicine & Public Health Mesenchyme Metalloproteinase Mice Mice, Inbred C57BL Mice, Knockout Microenvironments Neoplasm Invasiveness - pathology NF-κB protein Oncology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Prolongation Proteolysis Stem cell transplantation Stem cells Survival Tumor Microenvironment - physiology Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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