Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mouse model, we demonstrate a causal and reversible role for obesity in early PDAC progression, showing...

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Veröffentlicht in:	Cell 2020-05, Vol.181 (4), p.832-847.e18
Hauptverfasser:	Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Dias Costa, Andressa, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta cells Carcinogenesis - genetics Carcinoma, Pancreatic Ductal - etiology Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line Cell Line, Tumor Cell Transformation, Neoplastic - genetics cholecystokinin Disease Models, Animal Disease Progression Endocrine Cells - metabolism Exocrine Glands - metabolism Female Gene Expression Regulation, Neoplastic - genetics genetically engineered mouse models Humans leptin Male Mice Mice, Inbred C57BL Mutation - genetics obesity Obesity - genetics Obesity - metabolism pancreatic cancer pancreatic islets Pancreatic Neoplasms Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Signal Transduction - genetics tumor microenvironment Tumor Microenvironment - physiology
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