Central nervous system acute lymphoblastic leukemia: role of natural killer cells

Central nervous system acute lymphoblastic leukemia (CNS-ALL) is a major clinical problem. Prophylactic therapy is neurotoxic, and a third of the relapses involve the CNS. Increased expression of interleukin 15 (IL-15) in leukemic blasts is associated with increased risk for CNS-ALL. Using in vivo m...

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Veröffentlicht in:	Blood 2015-05, Vol.125 (22), p.3420-3431
Hauptverfasser:	Frishman-Levy, Liron, Shemesh, Avishai, Bar-Sinai, Allan, Ma, Chao, Ni, Zhenya, Frenkel, Shahar, Muench, Vera, Bruckmueller, Hilke, Vokuhl, Christian, Debatin, Klaus-Michael, Eckert, Cornelia, Stanulla, Martin, Schrappe, Martin, Campbell, Kerry S., Loewenthal, Ron, Schewe, Denis M., Hochman, Jacob, Meyer, Lueder H., Kaufman, Dan, Cario, Gunnar, Porgador, Angel, Izraeli, Shai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cells, Cultured Central Nervous System Neoplasms - immunology Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - mortality Central Nervous System Neoplasms - pathology Humans Interleukin-15 - metabolism Jurkat Cells Killer Cells, Natural - physiology Lymphoid Neoplasia Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Mice, Transgenic Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
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