Zika Virus NS3 Protease Pharmacophore Anchor Model and Drug Discovery

Zika virus (ZIKV) of the flaviviridae family, is the cause of emerging infections characterized by fever, Guillain-Barré syndrome (GBS) in adults and microcephaly in newborns. There exists an urgent unmet clinical need for anti-ZIKV drugs for the treatment of infected individuals. In the current wor...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.8929-8929, Article 8929
Hauptverfasser:	Pathak, Nikhil, Kuo, Yi-Ping, Chang, Teng-Yuan, Huang, Chin-Ting, Hung, Hui-Chen, Hsu, John Tsu-An, Yu, Guann-Yi, Yang, Jinn-Moon
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 13 13/109 14/33 42/44 631/114/2248 631/114/2397 692/699/255/2514 Antiviral agents Antiviral Agents - pharmacology Catalytic Domain - drug effects Drug discovery Drug Discovery - methods Fever Guillain-Barre syndrome Humanities and Social Sciences Microencephaly Models, Chemical Molecular Docking Simulation multidisciplinary Neonates Proteinase Science Science (multidisciplinary) Sequence Alignment Serine Endopeptidases - drug effects Therapeutic targets Viral Proteins - drug effects Zika virus Zika Virus - drug effects Zika Virus - enzymology Zika Virus - genetics
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