Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15

The long noncoding RNA HOTAIR plays significant roles in promoting cancer metastasis. However, how it conveys an invasive advantage in cancer cells is not clear. Here we identify the chondroitin sulfotransferase CHST15 (GalNAc4S‐6ST) as a novel HOX transcript antisense intergenic RNA (HOTAIR) target...

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Veröffentlicht in:	International journal of cancer 2019-11, Vol.145 (9), p.2478-2487
Hauptverfasser:	Liu, Liang‐Chih, Wang, Yuan‐Liang, Lin, Pei‐Le, Zhang, Xiang, Cheng, Wei‐Chung, Liu, Shu‐Hsuan, Chen, Chih‐Jung, Hung, Yu, Jan, Chia‐Ing, Chang, Ling‐Chu, Qi, Xiaoyang, Hsieh‐Wilson, Linda C., Wang, Shao‐Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense RNA Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cell surface Chondroitin sulfate CHST15 D-Galactosamine Disease Progression Female Gene Expression Regulation, Neoplastic - genetics Glycosaminoglycans HOTAIR Humans Hydroxyl groups Inhibition invasion Invasiveness Lesions long noncoding RNA Medical research Membrane Glycoproteins - genetics Metastases Metastasis Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology RNA Interference RNA, Long Noncoding - genetics RNA, Small Interfering - genetics RNA-mediated interference RNA‐seq Sulfates Sulfation Sulfotransferase Sulfotransferases - genetics Transcription Tumorigenesis Xenografts
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