Sphingosine kills bacteria by binding to cardiolipin

Sphingosine is a long-chain sphingoid base that has been shown to have bactericidal activity against many pathogens, including Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. We have previously demonstrated that sphingosine is present in nasal, tracheal, and bronchial epithelial...

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Veröffentlicht in:	The Journal of biological chemistry 2020-05, Vol.295 (22), p.7686-7696
Hauptverfasser:	Verhaegh, Rabea, Becker, Katrin Anne, Edwards, Michael J., Gulbins, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology bactericidal activity cardiolipin Cardiolipins - genetics Cardiolipins - metabolism Cell Membrane - genetics Cell Membrane - metabolism Escherichia coli - genetics Escherichia coli - growth & development innate immunity Lipids lung pathogen membrane permeabilization Pseudomonas aeruginosa (P. aeruginosa) Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - growth & development sphingoid base sphingolipid sphingosine Sphingosine - pharmacology Staphylococcus aureus (S. aureus) Staphylococcus aureus - genetics Staphylococcus aureus - growth & development
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