Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal cysteine protease, in mediating the behavioral deficits and neuropathology of these neurodegenerative diseases. This...

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Veröffentlicht in:	Biochimica et biophysica acta. Proteins and proteomics 2020-08, Vol.1868 (8), p.140428-140428, Article 140428
Hauptverfasser:	Hook, Vivian, Yoon, Michael, Mosier, Charles, Ito, Gen, Podvin, Sonia, Head, Brian P., Rissman, Robert, O'Donoghue, Anthony J., Hook, Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Active site binding Adult Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease (AD) Animals Behaviors Biomarker Brain Brain - drug effects Brain - enzymology Brain - pathology Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - enzymology Brain Injuries, Traumatic - genetics Brain Injuries, Traumatic - pathology Cathepsin B Cathepsin B - antagonists & inhibitors Cathepsin B - genetics Cathepsin B - metabolism Cell Death - drug effects Cell Death - genetics Child Cognition Cytosol - drug effects Cytosol - enzymology Disease Models, Animal Fetus Gene Expression Regulation Gene knockout Human brain Humans Infant Inhibitors Lysosomal leakage Lysosomes - drug effects Lysosomes - enzymology Memory Molecular Targeted Therapy Neurocognitive Disorders - drug therapy Neurocognitive Disorders - enzymology Neurocognitive Disorders - genetics Neurocognitive Disorders - pathology Neurodegeneration Neurons - drug effects Neurons - enzymology Neurons - pathology Neuroprotective Agents - therapeutic use Pathology Signal Transduction Traumatic brain injury (TBI)
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