A Phytocomplex Consisting of Tropaeolum majus L. and Salvia officinalis L. Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides
Background. The antimicrobial activity and effects of a phytocomplex consisting of Tropaeolum flos (T) and Salviae folium (S) extracts on the cytokine levels and transcription factors on dermal fibroblast BJ exposed to bacterial lipopolysaccharides were examined. Methods. In order to select the most...
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| creator | Crivii, Carmen Bianca Muresan, Mariana Micle, Otilia Vicaş, Laura Pallag, Annamaria Clichici, Simona V. Olteanu, Diana Filip, Gabriela A. Baldea, Ioana Jurca, Tunde Marian, Eleonora |
| description | Background. The antimicrobial activity and effects of a phytocomplex consisting of Tropaeolum flos (T) and Salviae folium (S) extracts on the cytokine levels and transcription factors on dermal fibroblast BJ exposed to bacterial lipopolysaccharides were examined. Methods. In order to select the most optimal combination ratio of the two extracts for using in vitro, the physicochemical characterization of vegetal extract mixtures was performed and the antioxidant and antibacterial activities were evaluated on five different formulations of T : S, namely, 1 : 1, 1 : 2, 2 : 1, 3 : 1, and 1 : 3. The best combination of bioactive compounds with regard to antioxidant and antibacterial activities (T : S 1 : 2) was selected for in vitro evaluation of the anti-inflammatory effect. Human dermal fibroblast BJ cells were treated with two doses of the extract mixture and then exposed to bacterial lipopolysaccharides (LPS). The levels of the cytokines involved in inflammatory response, namely, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, IL-31, and IL-33, were quantified by ELISA, and the expression of transcription factors, namely, signal transducer and activator of transcription (STAT) 3, nuclear factor kappa B (NFκB), and phosphorylated NFκB (pNFκB), were evaluated by western blot analysis. Results. The results have shown that the mixture of T : S 1 : 2 exhibited significant antibacterial effects on Staphylococcus aureus ATCC 25923. LPS exposure increased the cytokine levels in BJ cells and enhanced the NFκB expression. The pretreatment of BF cells exposed to LPS with the two doses of the extract mixture markedly inhibited the increase of IL-33 and TNF-α levels and amplified the NFκB expression and its activation, especially with the high dose. The low doses of the extract reduced NFκB expression but increased its activation. Conclusions. These experimental findings suggest that the mixture of T : S 1 : 2 can exert some protection against bacterial infections and inflammation induced by LPS in BJ cells being a good therapeutic option in related conditions associated with inflammation. |
| doi_str_mv | 10.1155/2020/8516153 |
| format | Article |
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Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Crivii, Carmen Bianca ; Muresan, Mariana ; Micle, Otilia ; Vicaş, Laura ; Pallag, Annamaria ; Clichici, Simona V. ; Olteanu, Diana ; Filip, Gabriela A. ; Baldea, Ioana ; Jurca, Tunde ; Marian, Eleonora</creator><contributor>Drevet, Joël R. ; Joël R Drevet</contributor><creatorcontrib>Crivii, Carmen Bianca ; Muresan, Mariana ; Micle, Otilia ; Vicaş, Laura ; Pallag, Annamaria ; Clichici, Simona V. ; Olteanu, Diana ; Filip, Gabriela A. ; Baldea, Ioana ; Jurca, Tunde ; Marian, Eleonora ; Drevet, Joël R. ; Joël R Drevet</creatorcontrib><description>Background. The antimicrobial activity and effects of a phytocomplex consisting of Tropaeolum flos (T) and Salviae folium (S) extracts on the cytokine levels and transcription factors on dermal fibroblast BJ exposed to bacterial lipopolysaccharides were examined. Methods. In order to select the most optimal combination ratio of the two extracts for using in vitro, the physicochemical characterization of vegetal extract mixtures was performed and the antioxidant and antibacterial activities were evaluated on five different formulations of T : S, namely, 1 : 1, 1 : 2, 2 : 1, 3 : 1, and 1 : 3. The best combination of bioactive compounds with regard to antioxidant and antibacterial activities (T : S 1 : 2) was selected for in vitro evaluation of the anti-inflammatory effect. Human dermal fibroblast BJ cells were treated with two doses of the extract mixture and then exposed to bacterial lipopolysaccharides (LPS). The levels of the cytokines involved in inflammatory response, namely, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, IL-31, and IL-33, were quantified by ELISA, and the expression of transcription factors, namely, signal transducer and activator of transcription (STAT) 3, nuclear factor kappa B (NFκB), and phosphorylated NFκB (pNFκB), were evaluated by western blot analysis. Results. The results have shown that the mixture of T : S 1 : 2 exhibited significant antibacterial effects on Staphylococcus aureus ATCC 25923. LPS exposure increased the cytokine levels in BJ cells and enhanced the NFκB expression. The pretreatment of BF cells exposed to LPS with the two doses of the extract mixture markedly inhibited the increase of IL-33 and TNF-α levels and amplified the NFκB expression and its activation, especially with the high dose. The low doses of the extract reduced NFκB expression but increased its activation. Conclusions. These experimental findings suggest that the mixture of T : S 1 : 2 can exert some protection against bacterial infections and inflammation induced by LPS in BJ cells being a good therapeutic option in related conditions associated with inflammation.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2020/8516153</identifier><identifier>PMID: 32566105</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Analysis ; Anti-Bacterial Agents - pharmacology ; Antimicrobial agents ; Antioxidants ; Antioxidants - pharmacology ; Bacterial infections ; Biomarkers - metabolism ; Cell Line ; Cell Survival - drug effects ; Cytokines ; Dermatitis ; Dermis - pathology ; Disease ; Fibroblasts - drug effects ; Fibroblasts - pathology ; Flavonoids ; Flavonoids - analysis ; Gardens & gardening ; Gene expression ; Humans ; Inflammation ; Inflammation - pathology ; Interleukin-6 - metabolism ; Interleukins ; Kinases ; Lipopolysaccharides ; Lymphocytes ; Microbial Sensitivity Tests ; NF-kappa B - metabolism ; Pathogenesis ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - analysis ; Pruritus ; Salvia officinalis - chemistry ; Skin ; Skin diseases ; STAT3 Transcription Factor - metabolism ; Tropaeolum - chemistry</subject><ispartof>Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14</ispartof><rights>Copyright © 2020 Tunde Jurca et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Tunde Jurca et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Tunde Jurca et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-78b1bfcaf3dcf012dacc1a6e4dac0bdc0c751f634b24dc8be9d6f615638236de3</citedby><cites>FETCH-LOGICAL-c499t-78b1bfcaf3dcf012dacc1a6e4dac0bdc0c751f634b24dc8be9d6f615638236de3</cites><orcidid>0000-0001-5328-333X ; 0000-0002-7447-4925 ; 0000-0002-3034-3659 ; 0000-0002-0046-0803 ; 0000-0002-8333-3219 ; 0000-0002-7146-3040 ; 0000-0003-4403-6091</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261326/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261326/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32566105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Drevet, Joël R.</contributor><contributor>Joël R Drevet</contributor><creatorcontrib>Crivii, Carmen Bianca</creatorcontrib><creatorcontrib>Muresan, Mariana</creatorcontrib><creatorcontrib>Micle, Otilia</creatorcontrib><creatorcontrib>Vicaş, Laura</creatorcontrib><creatorcontrib>Pallag, Annamaria</creatorcontrib><creatorcontrib>Clichici, Simona V.</creatorcontrib><creatorcontrib>Olteanu, Diana</creatorcontrib><creatorcontrib>Filip, Gabriela A.</creatorcontrib><creatorcontrib>Baldea, Ioana</creatorcontrib><creatorcontrib>Jurca, Tunde</creatorcontrib><creatorcontrib>Marian, Eleonora</creatorcontrib><title>A Phytocomplex Consisting of Tropaeolum majus L. and Salvia officinalis L. Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Background. The antimicrobial activity and effects of a phytocomplex consisting of Tropaeolum flos (T) and Salviae folium (S) extracts on the cytokine levels and transcription factors on dermal fibroblast BJ exposed to bacterial lipopolysaccharides were examined. Methods. In order to select the most optimal combination ratio of the two extracts for using in vitro, the physicochemical characterization of vegetal extract mixtures was performed and the antioxidant and antibacterial activities were evaluated on five different formulations of T : S, namely, 1 : 1, 1 : 2, 2 : 1, 3 : 1, and 1 : 3. The best combination of bioactive compounds with regard to antioxidant and antibacterial activities (T : S 1 : 2) was selected for in vitro evaluation of the anti-inflammatory effect. Human dermal fibroblast BJ cells were treated with two doses of the extract mixture and then exposed to bacterial lipopolysaccharides (LPS). The levels of the cytokines involved in inflammatory response, namely, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, IL-31, and IL-33, were quantified by ELISA, and the expression of transcription factors, namely, signal transducer and activator of transcription (STAT) 3, nuclear factor kappa B (NFκB), and phosphorylated NFκB (pNFκB), were evaluated by western blot analysis. Results. The results have shown that the mixture of T : S 1 : 2 exhibited significant antibacterial effects on Staphylococcus aureus ATCC 25923. LPS exposure increased the cytokine levels in BJ cells and enhanced the NFκB expression. The pretreatment of BF cells exposed to LPS with the two doses of the extract mixture markedly inhibited the increase of IL-33 and TNF-α levels and amplified the NFκB expression and its activation, especially with the high dose. The low doses of the extract reduced NFκB expression but increased its activation. Conclusions. These experimental findings suggest that the mixture of T : S 1 : 2 can exert some protection against bacterial infections and inflammation induced by LPS in BJ cells being a good therapeutic option in related conditions associated with inflammation.</description><subject>Acids</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Bacterial infections</subject><subject>Biomarkers - metabolism</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cytokines</subject><subject>Dermatitis</subject><subject>Dermis - pathology</subject><subject>Disease</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - pathology</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Gardens & gardening</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukins</subject><subject>Kinases</subject><subject>Lipopolysaccharides</subject><subject>Lymphocytes</subject><subject>Microbial Sensitivity Tests</subject><subject>NF-kappa B - metabolism</subject><subject>Pathogenesis</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Polyphenols - analysis</subject><subject>Pruritus</subject><subject>Salvia officinalis - chemistry</subject><subject>Skin</subject><subject>Skin diseases</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Tropaeolum - chemistry</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1u1DAUhSMEoqWwY40ssUGCaf2TeJIN0jC0UGkkEJS1deNcz7hy4tROSuepeEUcZpgCK1a2dD4f-x6fLHvO6CljRXHGKadnZcEkK8SD7JhVOZ_RqsofHvaUHmVPYrymVAqes8fZkeCFlIwWx9mPBfm82Q5e-7Z3eEeWvos2DrZbE2_IVfA9oHdjS1q4HiNZnRLoGvIV3K2FRBirbQfO_lLO74YAeohk4RwmfcBIhg2Sy844aFsYfNiSLxj7dAdO9u8xtODIha2Drx3EdHTw5F3ywGCTsLK9773bRtB6A8E2GJ9mjwy4iM_260n27eL8avlxtvr04XK5WM10XlXDbF7WrDYajGi0oYw3yYGBxDxtaN1oqucFM1LkNc8bXdZYNdKkBKUouZANipPs7c63H-sWG41dms2pPtgWwlZ5sOpvpbMbtfa3as4lE1wmg1d7g-BvRoyDam3U6Bx06Meo0kcUpeC8zBP68h_02o8hxTpRdF6ViSzvqTU4VLYzfkp7MlULKYqiTGOyRL3ZUTr4GAOaw5MZVVNf1NQXte9Lwl_8OeYB_l2QBLzeARvbNfDd_qcdJgYN3NOcpmyZ-An1qNWL</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Crivii, Carmen Bianca</creator><creator>Muresan, Mariana</creator><creator>Micle, Otilia</creator><creator>Vicaş, Laura</creator><creator>Pallag, Annamaria</creator><creator>Clichici, Simona V.</creator><creator>Olteanu, Diana</creator><creator>Filip, Gabriela A.</creator><creator>Baldea, Ioana</creator><creator>Jurca, Tunde</creator><creator>Marian, Eleonora</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5328-333X</orcidid><orcidid>https://orcid.org/0000-0002-7447-4925</orcidid><orcidid>https://orcid.org/0000-0002-3034-3659</orcidid><orcidid>https://orcid.org/0000-0002-0046-0803</orcidid><orcidid>https://orcid.org/0000-0002-8333-3219</orcidid><orcidid>https://orcid.org/0000-0002-7146-3040</orcidid><orcidid>https://orcid.org/0000-0003-4403-6091</orcidid></search><sort><creationdate>2020</creationdate><title>A Phytocomplex Consisting of Tropaeolum majus L. and Salvia officinalis L. Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides</title><author>Crivii, Carmen Bianca ; Muresan, Mariana ; Micle, Otilia ; Vicaş, Laura ; Pallag, Annamaria ; Clichici, Simona V. ; Olteanu, Diana ; Filip, Gabriela A. ; Baldea, Ioana ; Jurca, Tunde ; Marian, Eleonora</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-78b1bfcaf3dcf012dacc1a6e4dac0bdc0c751f634b24dc8be9d6f615638236de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Bacterial infections</topic><topic>Biomarkers - metabolism</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cytokines</topic><topic>Dermatitis</topic><topic>Dermis - pathology</topic><topic>Disease</topic><topic>Fibroblasts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crivii, Carmen Bianca</au><au>Muresan, Mariana</au><au>Micle, Otilia</au><au>Vicaş, Laura</au><au>Pallag, Annamaria</au><au>Clichici, Simona V.</au><au>Olteanu, Diana</au><au>Filip, Gabriela A.</au><au>Baldea, Ioana</au><au>Jurca, Tunde</au><au>Marian, Eleonora</au><au>Drevet, Joël R.</au><au>Joël R Drevet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Phytocomplex Consisting of Tropaeolum majus L. and Salvia officinalis L. Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Background. The antimicrobial activity and effects of a phytocomplex consisting of Tropaeolum flos (T) and Salviae folium (S) extracts on the cytokine levels and transcription factors on dermal fibroblast BJ exposed to bacterial lipopolysaccharides were examined. Methods. In order to select the most optimal combination ratio of the two extracts for using in vitro, the physicochemical characterization of vegetal extract mixtures was performed and the antioxidant and antibacterial activities were evaluated on five different formulations of T : S, namely, 1 : 1, 1 : 2, 2 : 1, 3 : 1, and 1 : 3. The best combination of bioactive compounds with regard to antioxidant and antibacterial activities (T : S 1 : 2) was selected for in vitro evaluation of the anti-inflammatory effect. Human dermal fibroblast BJ cells were treated with two doses of the extract mixture and then exposed to bacterial lipopolysaccharides (LPS). The levels of the cytokines involved in inflammatory response, namely, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, IL-31, and IL-33, were quantified by ELISA, and the expression of transcription factors, namely, signal transducer and activator of transcription (STAT) 3, nuclear factor kappa B (NFκB), and phosphorylated NFκB (pNFκB), were evaluated by western blot analysis. Results. The results have shown that the mixture of T : S 1 : 2 exhibited significant antibacterial effects on Staphylococcus aureus ATCC 25923. LPS exposure increased the cytokine levels in BJ cells and enhanced the NFκB expression. The pretreatment of BF cells exposed to LPS with the two doses of the extract mixture markedly inhibited the increase of IL-33 and TNF-α levels and amplified the NFκB expression and its activation, especially with the high dose. The low doses of the extract reduced NFκB expression but increased its activation. Conclusions. These experimental findings suggest that the mixture of T : S 1 : 2 can exert some protection against bacterial infections and inflammation induced by LPS in BJ cells being a good therapeutic option in related conditions associated with inflammation.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32566105</pmid><doi>10.1155/2020/8516153</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5328-333X</orcidid><orcidid>https://orcid.org/0000-0002-7447-4925</orcidid><orcidid>https://orcid.org/0000-0002-3034-3659</orcidid><orcidid>https://orcid.org/0000-0002-0046-0803</orcidid><orcidid>https://orcid.org/0000-0002-8333-3219</orcidid><orcidid>https://orcid.org/0000-0002-7146-3040</orcidid><orcidid>https://orcid.org/0000-0003-4403-6091</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14 |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7261326 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Acids Analysis Anti-Bacterial Agents - pharmacology Antimicrobial agents Antioxidants Antioxidants - pharmacology Bacterial infections Biomarkers - metabolism Cell Line Cell Survival - drug effects Cytokines Dermatitis Dermis - pathology Disease Fibroblasts - drug effects Fibroblasts - pathology Flavonoids Flavonoids - analysis Gardens & gardening Gene expression Humans Inflammation Inflammation - pathology Interleukin-6 - metabolism Interleukins Kinases Lipopolysaccharides Lymphocytes Microbial Sensitivity Tests NF-kappa B - metabolism Pathogenesis Plant Extracts - pharmacology Polyphenols Polyphenols - analysis Pruritus Salvia officinalis - chemistry Skin Skin diseases STAT3 Transcription Factor - metabolism Tropaeolum - chemistry |
| title | A Phytocomplex Consisting of Tropaeolum majus L. and Salvia officinalis L. Extracts Alleviates the Inflammatory Response of Dermal Fibroblasts to Bacterial Lipopolysaccharides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A04%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Phytocomplex%20Consisting%20of%20Tropaeolum%20majus%20L.%20and%20Salvia%20officinalis%20L.%20Extracts%20Alleviates%20the%20Inflammatory%20Response%20of%20Dermal%20Fibroblasts%20to%20Bacterial%20Lipopolysaccharides&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Crivii,%20Carmen%20Bianca&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2020/8516153&rft_dat=%3Cgale_pubme%3EA635580121%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2407981588&rft_id=info:pmid/32566105&rft_galeid=A635580121&rfr_iscdi=true |