Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes

Auditory experience drives neural circuit refinement during windows of heightened brain plasticity, but little is known about the genetic regulation of this developmental process. The primary auditory cortex (A1) of mice exhibits a critical period for thalamocortical connectivity between postnatal d...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-05, Vol.117 (21), p.11744-11752
Hauptverfasser:	Kalish, Brian T., Barkat, Tania R., Diel, Erin E., Zhang, Elizabeth J., Greenberg, Michael E., Hensch, Takao K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Auditory Cortex - growth & development Auditory Cortex - metabolism Auditory plasticity Biological Sciences Cell Nucleus - metabolism Circuits Cortex (auditory) Critical period Developmental plasticity Gene expression Gene Expression Regulation, Developmental - genetics Gene sequencing Genes Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Glutamatergic transmission Hearing Interneurons Mice Microglia Neural networks Neuroimaging Neuroplasticity Nogo protein Nogo Receptors - genetics Nogo Receptors - metabolism Oligodendrocytes Pattern formation Plastic properties Plasticity Ribonucleic acid RNA RNA - analysis RNA - genetics RNA - metabolism Sequence Analysis, RNA - methods Single-Cell Analysis - methods snRNA Somatosensory cortex Thalamus Transcription Transcriptome - genetics Transcriptomics γ-Aminobutyric acid
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