Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

Female fertility and offspring health are critically dependent on an adequate supply of high-quality oocytes, the majority of which are maintained in the ovaries in a unique state of meiotic prophase arrest. While mechanisms of DNA repair during meiotic recombination are well characterized, the same...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-05, Vol.117 (21), p.11513-11522
Hauptverfasser:	Stringer, Jessica M., Winship, Amy, Zerafa, Nadeen, Wakefield, Matthew, Hutt, Karla
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Ataxia telangiectasia Ataxia telangiectasia mutated protein Biological Sciences Damage localization Deoxyribonucleic acid DNA DNA damage DNA repair Fertility Gametocytes Genotoxicity Histone H2A Homologous recombination Homologous recombination repair Homology Integrity Irradiation Meiosis Offspring Oocytes Ovaries Prophase Quality control Radiation Repair
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