Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization

Patients with respiratory syncytial virus (RSV) infection exhibit enhanced susceptibility to subsequent pneumococcal infections. However, the underlying mechanisms involved in this increased susceptibility remain unclear. Here, we identified potentially novel cellular and molecular cascades triggere...

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Veröffentlicht in:	The Journal of clinical investigation 2020-06, Vol.130 (6), p.3021-3037
Hauptverfasser:	Shibata, Takehiko, Makino, Airi, Ogata, Ruiko, Nakamura, Shigeki, Ito, Toshihiro, Nagata, Kisaburo, Terauchi, Yoshihiko, Oishi, Taku, Fujieda, Mikiya, Takahashi, Yoshimasa, Ato, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Antibacterial activity Antibacterial agents Axl protein Bacterial infections Biomedical research Caspase-1 Cytokines - genetics Cytokines - immunology Disease susceptibility Genotype & phenotype Health aspects Infection Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - immunology Interleukin 18 Killer cells Macrophages Macrophages, Alveolar - immunology Macrophages, Alveolar - microbiology Macrophages, Alveolar - pathology Macrophages, Alveolar - virology Male Mice Mice, Knockout Natural killer cells Neutrophils Phenotypes Pneumococcal pneumonia Pneumonia Pneumonia, Pneumococcal - genetics Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - pathology Pneumonia, Pneumococcal - virology Protein expression Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - immunology Respiratory syncytial virus Respiratory Syncytial Virus Infections - genetics Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - pathology Respiratory Syncytial Viruses - immunology Software industry Streptococcus infections Therapeutic applications Tumor necrosis factor-α Virus diseases γ-Interferon
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