DNA hypermethylation during tuberculosis dampens host immune responsiveness

Mycobacterium tuberculosis (M. tuberculosis) has coevolved with humans for millennia and developed multiple mechanisms to evade host immunity. Restoring host immunity in order to improve outcomes and potentially shorten existing therapy will require identification of the full complement by which hos...

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Veröffentlicht in:	The Journal of clinical investigation 2020-06, Vol.130 (6), p.3113-3123
Hauptverfasser:	DiNardo, Andrew R, Rajapakshe, Kimal, Nishiguchi, Tomoki, Grimm, Sandra L, Mtetwa, Godwin, Dlamini, Qiniso, Kahari, Jaqueline, Mahapatra, Sanjana, Kay, Alexander, Maphalala, Gugu, Mace, Emily M, Makedonas, George, Cirillo, Jeffrey D, Netea, Mihai G, van Crevel, Reinout, Coarfa, Cristian, Mandalakas, Anna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens BCG Biomedical research Cell growth Cloning CXCL10 protein Cytotoxicity Deoxyribonucleic acid DNA DNA methylation DNA Methylation - immunology Epigenetics Gene expression Gene Expression Regulation - immunology Genes Genetic research Genotype & phenotype Health aspects HIV Human immunodeficiency virus Humans Immune response Infections Interleukin 1 Interleukin 12 Interleukin 2 Interleukin 6 Janus kinase Janus kinase 2 Leukocytes - immunology Leukocytes - pathology Lymphocytes Medical research Methylation Mitogens Mycobacterium tuberculosis - immunology NF-κB protein Papillomavirus infections Schistosomiasis Signal transduction Signal Transduction - immunology Stat5 protein Tuberculosis Tuberculosis - immunology Tuberculosis - pathology Tumor necrosis factor Tyk2 protein Viral infections γ-Interferon
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