Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication

The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. While, in recent years, progress has been made in understanding the role of Mre11 nuc...

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Veröffentlicht in:	Science advances 2020-05, Vol.6 (22), p.eaaz4126
Hauptverfasser:	Boeckemeier, L, Kraehenbuehl, R, Keszthelyi, A, Gasasira, M U, Vernon, E G, Beardmore, R, Vågbø, C B, Chaplin, D, Gollins, S, Krokan, H E, Lambert, S A E, Paizs, B, Hartsuiker, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology DNA DNA Replication DNA-Binding Proteins - metabolism Exonucleases - genetics Exonucleases - metabolism Gemcitabine Genetics Life Sciences SciAdv r-articles
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