TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer

Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune evasion. The transforming growth factor-β (TGF...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2020-06, Vol.77 (11), p.2103-2123
Hauptverfasser:	Hua, Wan, ten Dijke, Peter, Kostidis, Sarantos, Giera, Martin, Hornsveld, Marten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cell Biology Cell Respiration Choline Drug resistance Epithelial-Mesenchymal Transition Glycolysis Growth factors Humans Life Sciences Lipid Metabolism Lipids Mesenchyme Metabolism Metastases Mitochondria Mitochondria - metabolism Mitochondria - pathology Neoplasms - metabolism Neoplasms - pathology Redox properties Review Signal Transduction Signaling Transforming Growth Factor beta - metabolism Transforming growth factor-b
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