Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

OBJECTIVE:Pulmonary hypertension (PH) due to left heart disease (group 2), especially in the setting of heart failure with preserved ejection fraction (HFpEF), is the most common cause of PH worldwide; however, at present, there is no proven effective therapy available for its treatment. PH-HFpEF is...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2020-06, Vol.40 (6), p.1543-1558
Hauptverfasser:	Wang, Longfei, Halliday, Gunner, Huot, Joshua R., Satoh, Taijyu, Baust, Jeffrey J., Fisher, Amanda, Cook, Todd, Hu, Jian, Avolio, Theodore, Goncharov, Dmitry A., Bai, Yang, Vanderpool, Rebecca R., Considine, Robert V., Bonetto, Andrea, Tan, Jiangning, Bachman, Timothy N., Sebastiani, Andrea, McTiernan, Charles F., Mora, Ana L., Machado, Roberto F., Goncharova, Elena A., Gladwin, Mark T., Lai, Yen-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - drug effects AMP-Activated Protein Kinases - physiology Animals Antihypertensive Agents Diet, High-Fat Epoprostenol - analogs & derivatives Epoprostenol - therapeutic use Heart - drug effects Heart - physiopathology Heart Failure - complications Heart Failure - drug therapy Heart Failure - physiopathology Hyperglycemia - drug therapy Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Hypoglycemic Agents Insulin Resistance Male Metabolic Syndrome Metformin - therapeutic use Mice Mice, Inbred C57BL Obesity - etiology Obesity - physiopathology Rats Receptors, Leptin - genetics Stroke Volume - physiology
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