Galectin-3 Identifies a Subset of Macrophages With a Potential Beneficial Role in Atherosclerosis

OBJECTIVE:Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of galectin-3 in determining the inflammatory profile of macrophages and composition of atherosclerotic plaques. APPROACH AND R...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2020-06, Vol.40 (6), p.1491-1509
Hauptverfasser:	Di Gregoli, Karina, Somerville, Michelle, Bianco, Rosaria, Thomas, Anita C., Frankow, Aleksandra, Newby, Andrew C., George, Sarah J., Jackson, Christopher L., Johnson, Jason L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - pathology Basic Sciences Crosses, Genetic Female Galectin 3 - analysis Galectin 3 - deficiency Galectin 3 - physiology Humans Inflammation - pathology Macrophages - chemistry Macrophages - pathology Macrophages - physiology Male Matrix Metalloproteinase 12 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Knockout, ApoE Middle Aged Plaque, Atherosclerotic - pathology Signal Transduction - physiology Transforming Growth Factor beta - metabolism
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