Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni -Infected Women without Signs or Symptoms of Hepatosplenic Disease
Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with but...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2020-06, Vol.102 (6), p.1382-1385 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Klemperer, Katherine M Reust, Mary Juliet Lee, Myung Hee Corstjens, Paul L A M van Dam, Govert J Mazigo, Humphrey D Dupnik, Kathryn M Downs, Jennifer A |
| description | Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by
have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with
but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized
amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an
endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with (
= 22) and without (
= 31) infection (1.001 versus 0.949 EU/mL,
= 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL,
= 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in
infection introduce bacterial sources of endotoxin to the circulation. |
| doi_str_mv | 10.4269/ajtmh.19-0875 |
| format | Article |
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have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with
but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized
amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an
endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with (
= 22) and without (
= 31) infection (1.001 versus 0.949 EU/mL,
= 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL,
= 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in
infection introduce bacterial sources of endotoxin to the circulation.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.19-0875</identifier><identifier>PMID: 32124718</identifier><language>eng</language><publisher>United States: Institute of Tropical Medicine</publisher><subject>Adult ; Animals ; Bacteria ; Endotoxins - blood ; Female ; Humans ; Intestinal Diseases, Parasitic - blood ; Liver Diseases - parasitology ; Parasitic diseases ; Plasma ; Schistosoma mansoni ; Schistosomiasis mansoni - blood ; Splenic Diseases - parasitology ; Toxins ; Women</subject><ispartof>The American journal of tropical medicine and hygiene, 2020-06, Vol.102 (6), p.1382-1385</ispartof><rights>Copyright Institute of Tropical Medicine Jun 2020</rights><rights>The American Society of Tropical Medicine and Hygiene 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-292bc4e2bc02e31a031836933b7b6853c205e14cd86a85f3e253a69f5e6fac2b3</citedby><cites>FETCH-LOGICAL-c415t-292bc4e2bc02e31a031836933b7b6853c205e14cd86a85f3e253a69f5e6fac2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253122/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253122/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32124718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klemperer, Katherine M</creatorcontrib><creatorcontrib>Reust, Mary Juliet</creatorcontrib><creatorcontrib>Lee, Myung Hee</creatorcontrib><creatorcontrib>Corstjens, Paul L A M</creatorcontrib><creatorcontrib>van Dam, Govert J</creatorcontrib><creatorcontrib>Mazigo, Humphrey D</creatorcontrib><creatorcontrib>Dupnik, Kathryn M</creatorcontrib><creatorcontrib>Downs, Jennifer A</creatorcontrib><title>Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni -Infected Women without Signs or Symptoms of Hepatosplenic Disease</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by
have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with
but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized
amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an
endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with (
= 22) and without (
= 31) infection (1.001 versus 0.949 EU/mL,
= 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL,
= 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in
infection introduce bacterial sources of endotoxin to the circulation.</description><subject>Adult</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Endotoxins - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Diseases, Parasitic - blood</subject><subject>Liver Diseases - parasitology</subject><subject>Parasitic diseases</subject><subject>Plasma</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis mansoni - blood</subject><subject>Splenic Diseases - parasitology</subject><subject>Toxins</subject><subject>Women</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EotvCkSuyxIVLWo-dOMkFqSotXWlFkRbE0XK8k65XiR1sp9Azfxwv_RD0Mh5pnnnk0UvIG2DHJZftid6lcXsMbcGaunpGFlDWsgBZVs_JgjHGi1aK-oAcxrhjDBoO8JIcCA68rKFZkN9fBh1HTc_dxif_yzq6whscIj0NSD_7RJfOBNQRNzTP1mZrY_LR541Ru-idpcXS9WhSBr77ER39adPWz4mu7bWL1Ae6vh2n5Mfc9_QSJ533pwGdNfSjjXv1K_Ki10PE1_fvEfl2cf717LJYXX1anp2uClNClQre8s6UmAvjKEAzAY2QrRBd3cmmEoazCqE0m0bqpuoF8kpo2fYVyl4b3okj8uHOO83diBuDLgU9qCnYUYdb5bVV_0-c3aprf6PqbALOs-D9vSD4HzPGpEYbDQ6DdujnqLioWSZbsUffPUF3fg4un6d4CQKqGoTMVHFHmeBjDNg_fgaY2ser_saroFX7eDP_9t8LHumHPMUfGjejeA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Klemperer, Katherine M</creator><creator>Reust, Mary Juliet</creator><creator>Lee, Myung Hee</creator><creator>Corstjens, Paul L A M</creator><creator>van Dam, Govert J</creator><creator>Mazigo, Humphrey D</creator><creator>Dupnik, Kathryn M</creator><creator>Downs, Jennifer A</creator><general>Institute of Tropical Medicine</general><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200601</creationdate><title>Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni -Infected Women without Signs or Symptoms of Hepatosplenic Disease</title><author>Klemperer, Katherine M ; Reust, Mary Juliet ; Lee, Myung Hee ; Corstjens, Paul L A M ; van Dam, Govert J ; Mazigo, Humphrey D ; Dupnik, Kathryn M ; Downs, Jennifer A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-292bc4e2bc02e31a031836933b7b6853c205e14cd86a85f3e253a69f5e6fac2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Endotoxins - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Diseases, Parasitic - blood</topic><topic>Liver Diseases - parasitology</topic><topic>Parasitic diseases</topic><topic>Plasma</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiasis mansoni - blood</topic><topic>Splenic Diseases - parasitology</topic><topic>Toxins</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klemperer, Katherine M</creatorcontrib><creatorcontrib>Reust, Mary Juliet</creatorcontrib><creatorcontrib>Lee, Myung Hee</creatorcontrib><creatorcontrib>Corstjens, Paul L A M</creatorcontrib><creatorcontrib>van Dam, Govert J</creatorcontrib><creatorcontrib>Mazigo, Humphrey D</creatorcontrib><creatorcontrib>Dupnik, Kathryn M</creatorcontrib><creatorcontrib>Downs, Jennifer A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klemperer, Katherine M</au><au>Reust, Mary Juliet</au><au>Lee, Myung Hee</au><au>Corstjens, Paul L A M</au><au>van Dam, Govert J</au><au>Mazigo, Humphrey D</au><au>Dupnik, Kathryn M</au><au>Downs, Jennifer A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni -Infected Women without Signs or Symptoms of Hepatosplenic Disease</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>102</volume><issue>6</issue><spage>1382</spage><epage>1385</epage><pages>1382-1385</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><abstract>Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by
have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with
but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized
amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an
endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with (
= 22) and without (
= 31) infection (1.001 versus 0.949 EU/mL,
= 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL,
= 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in
infection introduce bacterial sources of endotoxin to the circulation.</abstract><cop>United States</cop><pub>Institute of Tropical Medicine</pub><pmid>32124718</pmid><doi>10.4269/ajtmh.19-0875</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Animals Bacteria Endotoxins - blood Female Humans Intestinal Diseases, Parasitic - blood Liver Diseases - parasitology Parasitic diseases Plasma Schistosoma mansoni Schistosomiasis mansoni - blood Splenic Diseases - parasitology Toxins Women |
| title | Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni -Infected Women without Signs or Symptoms of Hepatosplenic Disease |
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