Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19
Cytokine release and macrophage activation contribute to immunopathology after SARS-CoV-2 infection. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy.
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| Veröffentlicht in: | Cancer discovery 2020-06, Vol.10 (6), p.775-778 |
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| container_end_page | 778 |
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| container_title | Cancer discovery |
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| creator | Agarwal, Sangya June, Carl H |
| description | Cytokine release and macrophage activation contribute to immunopathology after SARS-CoV-2 infection. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy. |
| doi_str_mv | 10.1158/2159-8290.CD-20-0473 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 2159-8274 |
| ispartof | Cancer discovery, 2020-06, Vol.10 (6), p.775-778 |
| issn | 2159-8274 2159-8290 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7249633 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Betacoronavirus Calcineurin Inhibitors - therapeutic use Cell- and Tissue-Based Therapy Coronavirus Infections - complications Coronavirus Infections - epidemiology COVID-19 Cytokines - metabolism Drug Repositioning Humans Immunotherapy - methods In Focus Inflammation - epidemiology Inflammation - etiology Inflammation - therapy Lymphohistiocytosis, Hemophagocytic - etiology Lymphohistiocytosis, Hemophagocytic - prevention & control Lymphohistiocytosis, Hemophagocytic - therapy Macrophage Activation Morbidity Neoplasms - therapy Neoplasms - virology Pandemics Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Receptors, Antigen, T-Cell - immunology SARS-CoV-2 |
| title | Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19 |
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