Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane

1,4-Dioxane is a genotoxic carcinogen, and its mutagenic properties were recently observed in the liver of guanine phosphoribosyl transferase (gpt) delta transgenic rats. However, the mechanisms of its genotoxicity remain unclear. We analyzed DNA adduct formation in rat livers following 1,4-dioxane...

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Veröffentlicht in:	Proceedings of the Japan Academy Series B, 2020/05/11, Vol.96(5), pp.180-187
Hauptverfasser:	TOTSUKA, Yukari, MAESAKO, Yuya, ONO, Hanako, NAGAI, Momoko, KATO, Mamoru, GI, Min, WANIBUCHI, Hideki, FUKUSHIMA, Shoji, SHIIZAKI, Kazuhiro, NAKAGAMA, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-dioxane 8-Hydroxydeoxyguanosine Adducts Animals Carcinogens Chromatography Comparative analysis Cosmetics Deoxyribonucleic acid Dioxane Dioxanes - toxicity Discriminant analysis DNA DNA adduct DNA adducts DNA Adducts - metabolism Drinking water Genetic engineering Genetic testing Genotoxicity gpt delta rat Guanine Liver Liver - drug effects Liver - metabolism Mass spectrometry Mass spectroscopy Mutation Original Oxidative stress Principal components analysis Pyrimidines Rats Scientific imaging Software Solvents Thymine Uracil
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