Acid and Neutral Sphingomyelinase Behavior in Radiation-Induced Liver Pyroptosis and in the Protective/Preventive Role of rMnSOD

Sphingomyelins (SMs) are a class of relevant bioactive molecules that act as key modulators of different cellular processes, such as growth arrest, exosome formation, and the inflammatory response influenced by many environmental conditions, leading to pyroptosis, a form of programmed cell death due...

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Veröffentlicht in:	International journal of molecular sciences 2020-05, Vol.21 (9), p.3281
Hauptverfasser:	Cataldi, Samuela, Borrelli, Antonella, Ceccarini, Maria Rachele, Nakashidze, Irina, Codini, Michela, Belov, Oleg, Ivanov, Alexander, Krasavin, Eugene, Ferri, Ivana, Conte, Carmela, Patria, Federica Filomena, Beccari, Tommaso, Mancini, Aldo, Curcio, Francesco, Ambesi-Impiombato, Francesco Saverio, Albi, Elisabetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain research Caspase 1 - metabolism Caspase-1 Cell cycle Cell death Cell growth Cytology Design of experiments Endoplasmic reticulum Environmental conditions Enzymes Female Gene expression Immunomodulation Inflammation Inflammatory response Ionizing radiation Labeling Liver Liver - drug effects Liver - metabolism Liver - radiation effects Metabolism Mice Nuclear research Pretreatment Proteins Pyroptosis Radiation damage Radiation effects Radiation Injuries - drug therapy Radiation Injuries - metabolism Radiation-Protective Agents - pharmacology Radiation-Protective Agents - therapeutic use Sphingomyelin phosphodiesterase Sphingomyelin Phosphodiesterase - metabolism Sphingomyelins - metabolism Thyroid gland
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