The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

The transcription factor nuclear factor erythroid-2–related factor 2 (Nrf2) plays a critical role in reducing oxidative stress by promoting the expression of antioxidant genes. Both individuals with diabetes and preclinical diabetes models exhibit evidence of a defect in retinal Nrf2 activation. We...

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Veröffentlicht in:	The Journal of biological chemistry 2020-05, Vol.295 (21), p.7350-7361
Hauptverfasser:	Miller, William P., Sunilkumar, Siddharth, Giordano, Joseph F., Toro, Allyson L., Barber, Alistair J., Dennis, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line diabetes Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology glycogen synthase kinase 3 (GSK-3) Humans hyperglycemia Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Mice Mice, Knockout Molecular Bases of Disease NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2) Oxidative Stress post-translational modification (PTM) Proteolysis reactive oxygen species (ROS) retina Retina - metabolism Retina - pathology retinopathy Transcription Factors - genetics Transcription Factors - metabolism
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