Functional Lipids in Autoimmune Inflammatory Diseases
Lipids are apolar small molecules known not only as components of cell membranes but also, in recent literature, as modulators of different biological functions. Herein, we focused on the bioactive lipids that can influence the immune responses and inflammatory processes regulating vascular hyperrea...
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| Veröffentlicht in: | International journal of molecular sciences 2020-04, Vol.21 (9), p.3074 |
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| container_title | International journal of molecular sciences |
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| creator | Cas, Michele Dei Roda, Gabriella Li, Feng Secundo, Francesco |
| description | Lipids are apolar small molecules known not only as components of cell membranes but also, in recent literature, as modulators of different biological functions. Herein, we focused on the bioactive lipids that can influence the immune responses and inflammatory processes regulating vascular hyperreactivity, pain, leukocyte trafficking, and clearance. In the case of excessive pro-inflammatory lipid activity, these lipids also contribute to the transition from acute to chronic inflammation. Based on their biochemical function, these lipids can be divided into different families, including eicosanoids, specialized pro-resolving mediators, lysoglycerophospholipids, sphingolipids, and endocannabinoids. These bioactive lipids are involved in all phases of the inflammatory process and the pathophysiology of different chronic autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, type-1 diabetes, and systemic lupus erythematosus. |
| doi_str_mv | 10.3390/ijms21093074 |
| format | Article |
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Herein, we focused on the bioactive lipids that can influence the immune responses and inflammatory processes regulating vascular hyperreactivity, pain, leukocyte trafficking, and clearance. In the case of excessive pro-inflammatory lipid activity, these lipids also contribute to the transition from acute to chronic inflammation. Based on their biochemical function, these lipids can be divided into different families, including eicosanoids, specialized pro-resolving mediators, lysoglycerophospholipids, sphingolipids, and endocannabinoids. 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Roda, Gabriella ; Li, Feng ; Secundo, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-36f2c0f222f81763702ac3f1372b6540483ad28eec0114ac289556f22730171e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - etiology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Autoimmune Diseases - therapy</topic><topic>Biological activity</topic><topic>Biomarkers</topic><topic>Biotechnology</topic><topic>Cannabinoids</topic><topic>Cartilage</topic><topic>Cell adhesion & migration</topic><topic>Cell membranes</topic><topic>Chronic conditions</topic><topic>Chronic illnesses</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Disease</topic><topic>Disease Management</topic><topic>Disease Susceptibility</topic><topic>Eicosanoids</topic><topic>Fatty acids</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Hyperreactivity</topic><topic>Immune clearance</topic><topic>Immune response</topic><topic>Inflammation</topic><topic>Inflammation - diagnosis</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - therapy</topic><topic>Inflammatory diseases</topic><topic>Kinases</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Metabolic Networks and Pathways</topic><topic>Multiple sclerosis</topic><topic>Pathogenesis</topic><topic>Plasma</topic><topic>Review</topic><topic>Rheumatoid arthritis</topic><topic>Sphingolipids</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cas, Michele Dei</creatorcontrib><creatorcontrib>Roda, Gabriella</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Secundo, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cas, Michele Dei</au><au>Roda, Gabriella</au><au>Li, Feng</au><au>Secundo, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Lipids in Autoimmune Inflammatory Diseases</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-04-27</date><risdate>2020</risdate><volume>21</volume><issue>9</issue><spage>3074</spage><pages>3074-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Lipids are apolar small molecules known not only as components of cell membranes but also, in recent literature, as modulators of different biological functions. Herein, we focused on the bioactive lipids that can influence the immune responses and inflammatory processes regulating vascular hyperreactivity, pain, leukocyte trafficking, and clearance. In the case of excessive pro-inflammatory lipid activity, these lipids also contribute to the transition from acute to chronic inflammation. Based on their biochemical function, these lipids can be divided into different families, including eicosanoids, specialized pro-resolving mediators, lysoglycerophospholipids, sphingolipids, and endocannabinoids. 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| subjects | Animals Apoptosis Arthritis Autoimmune diseases Autoimmune Diseases - diagnosis Autoimmune Diseases - etiology Autoimmune Diseases - metabolism Autoimmune Diseases - therapy Biological activity Biomarkers Biotechnology Cannabinoids Cartilage Cell adhesion & migration Cell membranes Chronic conditions Chronic illnesses Cytokines Diabetes Diabetes mellitus Disease Disease Management Disease Susceptibility Eicosanoids Fatty acids Growth factors Humans Hyperreactivity Immune clearance Immune response Inflammation Inflammation - diagnosis Inflammation - etiology Inflammation - metabolism Inflammation - therapy Inflammatory diseases Kinases Lipid Metabolism Lipids Metabolic Networks and Pathways Multiple sclerosis Pathogenesis Plasma Review Rheumatoid arthritis Sphingolipids Systemic lupus erythematosus |
| title | Functional Lipids in Autoimmune Inflammatory Diseases |
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