Matrix-transmitted paratensile signaling enables myofibroblast–fibroblast cross talk in fibrosis expansion

While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context ofmyofibroblast–fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-05, Vol.117 (20), p.10832-10838
Hauptverfasser:	Liu, Longwei, Yu, Hongsheng, Zhao, Hui, Wu, Zhaozhao, Long, Yi, Zhang, Jingbo, Yan, Xiaojun, You, Zhifeng, Zhou, Lyu, Xia, Tie, Shi, Yan, Xiao, Bailong, Wang, Yingxiao, Huang, Chenyu, Du, Yanan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Calcium signalling Cell signaling Collagen Crosstalk Discoidin Domain Receptor 2 - metabolism Fibers Fibroblasts Fibroblasts - metabolism Fibrosis Fibrosis - metabolism Growth models Humans Integrins Ion channels Ion Channels - metabolism Mathematical analysis Mathematical models Matrix methods Mechanotransduction Mechanotransduction, Cellular Myofibroblasts - metabolism Physical Sciences Signal Transduction - physiology Signaling
Online-Zugang:	Volltext
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