Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice

OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes. These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopath...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-14
Hauptverfasser:	Zhou, Shanshan, Zhang, Jian, Jiang, Saizhi, Tang, Xiaoqiang, Zheng, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Animals Antibodies Blood sugar Calcium-binding proteins Calmodulin - genetics Calmodulin - metabolism Cardiomyopathy Cardiovascular disease Collagen Diabetes Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Diabetic nephropathy Disease Models, Animal Disease Progression Female Females Fibrosis Gender differences Genetic engineering Heart Heart diseases Heart failure Humans Hyperglycemia Hypertension Insulin-Secreting Cells - metabolism Laboratory animals Male Males Mice Mice, Transgenic Myocardium - metabolism Myocardium - pathology Pancreatic beta cells Proteins Sex Characteristics Type 1 diabetes Type 2 diabetes
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