CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular psychiatry 2020-06, Vol.25 (6), p.1175-1190
Hauptverfasser:	Zhang, Yuan, Du, Longfei, Bai, Ying, Han, Bing, He, Cancan, Gong, Liang, Huang, Rongrong, Shen, Ling, Chao, Jie, Liu, Pei, Zhang, Hongxing, Zhang, Haisan, Gu, Ling, Li, Junxu, Hu, Gang, Xie, Chunming, Zhang, Zhijun, Yao, Honghong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/21 13/51 14/19 14/32 38 38/77 38/90 631/337 631/378 64/60 Alzheimer's disease Analysis Animal models Animals Behavioral Sciences Biological Psychology Central nervous system Circular RNA Depression, Mental Depressive Disorder, Major - genetics Disease Models, Animal Heat shock proteins Hospitals HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Laboratories Lipopolysaccharides Male Medicine Medicine & Public Health Mental depression Mental disorders Mice Mice, Inbred C57BL Microglia - metabolism MicroRNAs MicroRNAs - genetics miRNA Mitogens Neurosciences Pathogenesis Pathophysiology Peripheral blood Pharmacology Pharmacotherapy Psychiatry Public health RNA RNA, Circular - genetics Therapeutic applications Type 2 diabetes Ubiquitin Ubiquitin-protein ligase Ubiquitination Ubiquitination - genetics Zhang Yuan
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!