A review on possible modes of action of chloroquine/hydroxychloroquine: repurposing against SAR-CoV-2 (COVID-19) pandemic

•Chloroquine (CQ) has diverse modes of action against viral infections.•CQ may interfere with SARS-CoV-2 attachment to the host ACE2 receptor.•CQ may hamper the STING pathway to attenuate the pro-inflammatory response.•Hydroxychloroquine (HCQ) might be a logical approach in the treatment of SARS-CoV...

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Veröffentlicht in:	International journal of antimicrobial agents 2020-08, Vol.56 (2), p.106028-106028, Article 106028
Hauptverfasser:	Tripathy, Satyajit, Dassarma, Barsha, Roy, Somenath, Chabalala, Hlupheka, Matsabisa, Motlalepula Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Antiviral Agents - pharmacology Betacoronavirus - metabolism Chloroquine Chloroquine - pharmacology Coronavirus Infections - drug therapy Coronavirus Infections - metabolism COVID-19 Drug Repositioning Humans Hydroxychloroquine Hydroxychloroquine - pharmacology Pandemic Pandemics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - drug therapy Pneumonia, Viral - metabolism SARS-CoV-2
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