Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse β-cells, LDs are prominent in human β-cells. However, the regulation of LD mobilization (lipolysis) in human β-cells remains unclear. We found that glucose increases lip...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (6), p.1178-1192
Hauptverfasser:	Liu, Siming, Promes, Joseph A, Harata, Mikako, Mishra, Akansha, Stephens, Samuel B, Taylor, Eric B, Burand, Jr, Anthony J, Sivitz, William I, Fink, Brian D, Ankrum, James A, Imai, Yumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Diabetes Diabetes mellitus (non-insulin dependent) Down-Regulation Gene Expression Regulation, Enzymologic - physiology Glucose Humans Insulin Insulin - metabolism Insulin secretion Insulin-Secreting Cells - physiology Islet Studies Lipase Lipase - genetics Lipase - metabolism Lipid Droplets - physiology Lipids Lipolysis Mice Mice, Inbred C57BL Mice, Knockout Oxygen - metabolism Oxygen Consumption Palmitoylation Potassium chloride Proteasomes Secretion SNAP receptors Syntaxin Syntaxin 1 Syntaxin 1 - genetics Syntaxin 1 - metabolism Triglycerides
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