The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury

Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects. However, its potential to...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-17
Hauptverfasser:	Song, Chunhui, Williams, Kevin, Liu, Changhui, Xu, Qin, Chang, Yongsheng, Gao, Yong, Gao, Weihang, Yang, Zehong, Cheng, Bo, Zhang, Yuan, Yang, Xingping, Wei, Li, Zhang, Jiecheng, Gao, Zhao, Miao, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - adverse effects Acids Acute Disease Analgesics Animal experimentation Animals Antioxidants - metabolism Bile Cytokines Cytokines - metabolism Drug dosages Drug Overdose - drug therapy Drug Overdose - genetics Drug Overdose - pathology Drugs Experiments Furocoumarins - chemistry Furocoumarins - pharmacology Furocoumarins - therapeutic use Gene amplification Gene Expression Regulation - drug effects Health aspects Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Inflammation Inflammation Mediators - metabolism Laboratories Lipopolysaccharides Liver Liver - injuries Liver - pathology Male Mice, Inbred C57BL Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Models, Biological Overdose Oxidative stress Oxidative Stress - drug effects Protective Agents - pharmacology Protective Agents - therapeutic use Proteins Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction - drug effects Sirtuin 1 - metabolism Transcriptome - genetics Up-Regulation
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