Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance
Carbohydrate response element binding protein (ChREBP) is a glucose-sensing transcription factor that mediates the induction of glycolytic and lipogenic genes in response to glucose. We investigated the expression patterns of ChREBP and glucose transporters (GLUTs) in human hepatocellular carcinoma...
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| Veröffentlicht in: | Pathology oncology research 2020-04, Vol.26 (2), p.1331-1340 |
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| description | Carbohydrate response element binding protein (ChREBP) is a glucose-sensing transcription factor that mediates the induction of glycolytic and lipogenic genes in response to glucose. We investigated the expression patterns of ChREBP and glucose transporters (GLUTs) in human hepatocellular carcinoma (HCC) and their association with HCC progression. ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent tissue and cancer tissue of different HCC stages. The effect of HCC malignancy on protein expression was analyzed with one-way ANOVA. The correlations between protein expressions were analyzed with Pearson Correlation test. We found that ChREBP protein expression tended to be positively correlated to liver malignancy. GLUT2 protein expression was significantly reduced in human HCC as compared to normal liver tissue and its expression in HCC was inversely associated to malignancy (
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| doi_str_mv | 10.1007/s12253-019-00708-y |
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p
< 0.001). In contrast, GLUT1 was significantly increased in cancer cells and its expression was positively correlated to malignancy (
p
< 0.001). Furthermore, GLUT1 expression was positively associated to ChREBP expression (r = 0.481,
p
< 0.0001,
n
= 70) but negatively correlated to GLUT2 expression (r = −0.320,
p
= 0.007, n = 70). Notably, ChREBP-expressing hepatocytes did not express GLUT2 but GLUT1. This is the first report unveiling expressions of ChREBP and GLUT2/GLUT1 and their relations in HCC. The expression patterns are related to malignancy and this information would facilitate evaluation of clinical behavior and treatment of HCC.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-019-00708-y</identifier><identifier>PMID: 31407220</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis ; Biomarkers, Tumor - analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carbohydrates ; Carcinoma, Hepatocellular - pathology ; Chemoreception ; Clinical significance ; Female ; Glucose ; Glucose transporter ; Glucose Transporter Type 1 - biosynthesis ; Glucose Transporter Type 2 - biosynthesis ; GLUT2 protein ; Glycolysis ; Hepatocellular carcinoma ; Hepatocytes ; Humans ; Immunohistochemistry ; Immunology ; Liver ; Liver cancer ; Liver Neoplasms - pathology ; Male ; Malignancy ; Medical diagnosis ; Middle Aged ; Oncology ; Original ; Original Article ; Pathology ; Protein expression ; Protein transport ; Proteins ; Tissues ; Variance analysis</subject><ispartof>Pathology oncology research, 2020-04, Vol.26 (2), p.1331-1340</ispartof><rights>The Author(s) 2019</rights><rights>Pathology & Oncology Research is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-e1e1e7a7094d8aba070481a6fe7efe92144664ccc7d2f0dcaa948d6c26451b73</citedby><cites>FETCH-LOGICAL-c502t-e1e1e7a7094d8aba070481a6fe7efe92144664ccc7d2f0dcaa948d6c26451b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-019-00708-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-019-00708-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31407220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Yu</creatorcontrib><creatorcontrib>Hu, Qiaoling</creatorcontrib><creatorcontrib>Gu, Jiang</creatorcontrib><title>Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Carbohydrate response element binding protein (ChREBP) is a glucose-sensing transcription factor that mediates the induction of glycolytic and lipogenic genes in response to glucose. We investigated the expression patterns of ChREBP and glucose transporters (GLUTs) in human hepatocellular carcinoma (HCC) and their association with HCC progression. ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent tissue and cancer tissue of different HCC stages. The effect of HCC malignancy on protein expression was analyzed with one-way ANOVA. The correlations between protein expressions were analyzed with Pearson Correlation test. We found that ChREBP protein expression tended to be positively correlated to liver malignancy. GLUT2 protein expression was significantly reduced in human HCC as compared to normal liver tissue and its expression in HCC was inversely associated to malignancy (
p
< 0.001). In contrast, GLUT1 was significantly increased in cancer cells and its expression was positively correlated to malignancy (
p
< 0.001). Furthermore, GLUT1 expression was positively associated to ChREBP expression (r = 0.481,
p
< 0.0001,
n
= 70) but negatively correlated to GLUT2 expression (r = −0.320,
p
= 0.007, n = 70). Notably, ChREBP-expressing hepatocytes did not express GLUT2 but GLUT1. This is the first report unveiling expressions of ChREBP and GLUT2/GLUT1 and their relations in HCC. The expression patterns are related to malignancy and this information would facilitate evaluation of clinical behavior and treatment of HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carbohydrates</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Chemoreception</subject><subject>Clinical significance</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose transporter</subject><subject>Glucose Transporter Type 1 - biosynthesis</subject><subject>Glucose Transporter Type 2 - biosynthesis</subject><subject>GLUT2 protein</subject><subject>Glycolysis</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Protein expression</subject><subject>Protein transport</subject><subject>Proteins</subject><subject>Tissues</subject><subject>Variance analysis</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kktv1DAUhS0EoqXwB1ggS2zYBOwbx042SHQ0FKSRQDB7y-PcTF1l7MFOKmbFX-eWKeWxqLzw43z32Ee-jD2X4rUUwrwpEqCpKyG7irairQ4P2KlsaqigFeYhrYEk1TX6hD0p5UoQpTv9mJ3UUgkDIE7Zj-X3fcZSQoqFp4EvXN6ky0Of3YT8C5Y9nSNfjrjDOPHzEPsQt_xzThOGyF3s-cU4-0TMOrtIeJ4wF07aKlxjJr_oaboBF2OIwbuRfw3bGAZakvSUPRrcWPDZ7XzG1u-X68WHavXp4uPi3aryjYCpQknDOCM61bdu4yiuaqXTAxocsAOplNbKe296GETvnetU22sPWjVyY-oz9vZou583O-w9hclutPscdi4fbHLB_qvEcGm36doaUABtTQavbg1y-jZjmewuFI_j6CKmuVgAA6ZuZdMR-vI_9CrNOVI6C0o02iij63sp8qJ4dSeIgiPlcyol43D3ZCnsTRPYYxNYagL7qwnsgYpe_B32ruT3rxNQH4FCUtxi_nP3PbY_AfmLv3A</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Lei, Yu</creator><creator>Hu, Qiaoling</creator><creator>Gu, Jiang</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance</title><author>Lei, Yu ; Hu, Qiaoling ; Gu, Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-e1e1e7a7094d8aba070481a6fe7efe92144664ccc7d2f0dcaa948d6c26451b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carbohydrates</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Chemoreception</topic><topic>Clinical significance</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose transporter</topic><topic>Glucose Transporter Type 1 - biosynthesis</topic><topic>Glucose Transporter Type 2 - biosynthesis</topic><topic>GLUT2 protein</topic><topic>Glycolysis</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Protein expression</topic><topic>Protein transport</topic><topic>Proteins</topic><topic>Tissues</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lei, Yu</creatorcontrib><creatorcontrib>Hu, Qiaoling</creatorcontrib><creatorcontrib>Gu, Jiang</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lei, Yu</au><au>Hu, Qiaoling</au><au>Gu, Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>26</volume><issue>2</issue><spage>1331</spage><epage>1340</epage><pages>1331-1340</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Carbohydrate response element binding protein (ChREBP) is a glucose-sensing transcription factor that mediates the induction of glycolytic and lipogenic genes in response to glucose. We investigated the expression patterns of ChREBP and glucose transporters (GLUTs) in human hepatocellular carcinoma (HCC) and their association with HCC progression. ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent tissue and cancer tissue of different HCC stages. The effect of HCC malignancy on protein expression was analyzed with one-way ANOVA. The correlations between protein expressions were analyzed with Pearson Correlation test. We found that ChREBP protein expression tended to be positively correlated to liver malignancy. GLUT2 protein expression was significantly reduced in human HCC as compared to normal liver tissue and its expression in HCC was inversely associated to malignancy (
p
< 0.001). In contrast, GLUT1 was significantly increased in cancer cells and its expression was positively correlated to malignancy (
p
< 0.001). Furthermore, GLUT1 expression was positively associated to ChREBP expression (r = 0.481,
p
< 0.0001,
n
= 70) but negatively correlated to GLUT2 expression (r = −0.320,
p
= 0.007, n = 70). Notably, ChREBP-expressing hepatocytes did not express GLUT2 but GLUT1. This is the first report unveiling expressions of ChREBP and GLUT2/GLUT1 and their relations in HCC. The expression patterns are related to malignancy and this information would facilitate evaluation of clinical behavior and treatment of HCC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31407220</pmid><doi>10.1007/s12253-019-00708-y</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis Biomarkers, Tumor - analysis Biomedical and Life Sciences Biomedicine Cancer Research Carbohydrates Carcinoma, Hepatocellular - pathology Chemoreception Clinical significance Female Glucose Glucose transporter Glucose Transporter Type 1 - biosynthesis Glucose Transporter Type 2 - biosynthesis GLUT2 protein Glycolysis Hepatocellular carcinoma Hepatocytes Humans Immunohistochemistry Immunology Liver Liver cancer Liver Neoplasms - pathology Male Malignancy Medical diagnosis Middle Aged Oncology Original Original Article Pathology Protein expression Protein transport Proteins Tissues Variance analysis |
| title | Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance |
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