Potential influence of COVID-19/ACE2 on the female reproductive system
Abstract The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-ang...
Gespeichert in:
| Veröffentlicht in: | Molecular human reproduction 2020-06, Vol.26 (6), p.367-373 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 373 |
|---|---|
| container_issue | 6 |
| container_start_page | 367 |
| container_title | Molecular human reproduction |
| container_volume | 26 |
| creator | Jing, Yan Run-Qian, Li Hao-Ran, Wang Hao-Ran, Chen Ya-Bin, Liu Yang, Gao Fei, Chen |
| description | Abstract
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2. |
| doi_str_mv | 10.1093/molehr/gaaa030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7239105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/molehr/gaaa030</oup_id><sourcerecordid>2398617235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c563t-dc4533575b951a7c61ccd1fac2ab44c4f370acc7d7091099c26bcc5020fd024c3</originalsourceid><addsrcrecordid>eNqFkM9PwjAYQBujEUSvHs2Oehj0x7qxiwmZoCYkeFCvTfetg5ltne1Gwn9vyZDgyVOb9PX160PoluAxwTGbVLpUGzNZSykxw2doSIIQ-zTA0fnJfoCurP3CmESUTy_RgFEWcjLFQ7R4062q20KWXlHnZadqUJ7OvWT1-frkk3gyS-bU07XXbpSXq0qWyjOqMTrroC22yrM726rqGl3ksrTq5rCO0Mdi_p68-MvV82syW_rAQ9b6GQScMR7xNOZERhASgIzkEqhMgwCCnEVYAkRZhGP3vRhomAJwTHGeYRoAG6HH3tt0aaUycKMbWYrGFJU0O6FlIf6e1MVGrPVWRJQ5I3eC-4PA6O9O2VZUhQVVlrJWurPCYdPQZWJ7dNyjYLS1RuXHZwgW-_iijy8O8d2Fu9PhjvhvbQc89IDumv9kP34okIE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398617235</pqid></control><display><type>article</type><title>Potential influence of COVID-19/ACE2 on the female reproductive system</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Jing, Yan ; Run-Qian, Li ; Hao-Ran, Wang ; Hao-Ran, Chen ; Ya-Bin, Liu ; Yang, Gao ; Fei, Chen</creator><creatorcontrib>Jing, Yan ; Run-Qian, Li ; Hao-Ran, Wang ; Hao-Ran, Chen ; Ya-Bin, Liu ; Yang, Gao ; Fei, Chen</creatorcontrib><description>Abstract
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.</description><identifier>ISSN: 1460-2407</identifier><identifier>ISSN: 1360-9947</identifier><identifier>EISSN: 1460-2407</identifier><identifier>DOI: 10.1093/molehr/gaaa030</identifier><identifier>PMID: 32365180</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Angiotensin I - genetics ; Angiotensin I - metabolism ; Angiotensin II - genetics ; Angiotensin II - metabolism ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus - pathogenicity ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - pathology ; Coronavirus Infections - transmission ; COVID-19 ; Female ; Gene Expression Regulation ; Genitalia, Female - pathology ; Genitalia, Female - virology ; Host-Pathogen Interactions - genetics ; Humans ; Pandemics ; Peptide Fragments - genetics ; Peptide Fragments - metabolism ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - metabolism ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - pathology ; Pneumonia, Viral - transmission ; Pregnancy ; Protein Binding ; Receptors, Virus - genetics ; Receptors, Virus - metabolism ; Renin-Angiotensin System - genetics ; Review ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus - genetics ; Spike Glycoprotein, Coronavirus - metabolism</subject><ispartof>Molecular human reproduction, 2020-06, Vol.26 (6), p.367-373</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-dc4533575b951a7c61ccd1fac2ab44c4f370acc7d7091099c26bcc5020fd024c3</citedby><cites>FETCH-LOGICAL-c563t-dc4533575b951a7c61ccd1fac2ab44c4f370acc7d7091099c26bcc5020fd024c3</cites><orcidid>0000-0002-2578-7159</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32365180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jing, Yan</creatorcontrib><creatorcontrib>Run-Qian, Li</creatorcontrib><creatorcontrib>Hao-Ran, Wang</creatorcontrib><creatorcontrib>Hao-Ran, Chen</creatorcontrib><creatorcontrib>Ya-Bin, Liu</creatorcontrib><creatorcontrib>Yang, Gao</creatorcontrib><creatorcontrib>Fei, Chen</creatorcontrib><title>Potential influence of COVID-19/ACE2 on the female reproductive system</title><title>Molecular human reproduction</title><addtitle>Mol Hum Reprod</addtitle><description>Abstract
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.</description><subject>Adult</subject><subject>Angiotensin I - genetics</subject><subject>Angiotensin I - metabolism</subject><subject>Angiotensin II - genetics</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin-Converting Enzyme 2</subject><subject>Betacoronavirus - pathogenicity</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - transmission</subject><subject>COVID-19</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Genitalia, Female - pathology</subject><subject>Genitalia, Female - virology</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Humans</subject><subject>Pandemics</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - pathology</subject><subject>Pneumonia, Viral - transmission</subject><subject>Pregnancy</subject><subject>Protein Binding</subject><subject>Receptors, Virus - genetics</subject><subject>Receptors, Virus - metabolism</subject><subject>Renin-Angiotensin System - genetics</subject><subject>Review</subject><subject>SARS-CoV-2</subject><subject>Spike Glycoprotein, Coronavirus - genetics</subject><subject>Spike Glycoprotein, Coronavirus - metabolism</subject><issn>1460-2407</issn><issn>1360-9947</issn><issn>1460-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwjAYQBujEUSvHs2Oehj0x7qxiwmZoCYkeFCvTfetg5ltne1Gwn9vyZDgyVOb9PX160PoluAxwTGbVLpUGzNZSykxw2doSIIQ-zTA0fnJfoCurP3CmESUTy_RgFEWcjLFQ7R4062q20KWXlHnZadqUJ7OvWT1-frkk3gyS-bU07XXbpSXq0qWyjOqMTrroC22yrM726rqGl3ksrTq5rCO0Mdi_p68-MvV82syW_rAQ9b6GQScMR7xNOZERhASgIzkEqhMgwCCnEVYAkRZhGP3vRhomAJwTHGeYRoAG6HH3tt0aaUycKMbWYrGFJU0O6FlIf6e1MVGrPVWRJQ5I3eC-4PA6O9O2VZUhQVVlrJWurPCYdPQZWJ7dNyjYLS1RuXHZwgW-_iijy8O8d2Fu9PhjvhvbQc89IDumv9kP34okIE</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Jing, Yan</creator><creator>Run-Qian, Li</creator><creator>Hao-Ran, Wang</creator><creator>Hao-Ran, Chen</creator><creator>Ya-Bin, Liu</creator><creator>Yang, Gao</creator><creator>Fei, Chen</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2578-7159</orcidid></search><sort><creationdate>20200601</creationdate><title>Potential influence of COVID-19/ACE2 on the female reproductive system</title><author>Jing, Yan ; Run-Qian, Li ; Hao-Ran, Wang ; Hao-Ran, Chen ; Ya-Bin, Liu ; Yang, Gao ; Fei, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-dc4533575b951a7c61ccd1fac2ab44c4f370acc7d7091099c26bcc5020fd024c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Angiotensin I - genetics</topic><topic>Angiotensin I - metabolism</topic><topic>Angiotensin II - genetics</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin-Converting Enzyme 2</topic><topic>Betacoronavirus - pathogenicity</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronavirus Infections - transmission</topic><topic>COVID-19</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Genitalia, Female - pathology</topic><topic>Genitalia, Female - virology</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Humans</topic><topic>Pandemics</topic><topic>Peptide Fragments - genetics</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - pathology</topic><topic>Pneumonia, Viral - transmission</topic><topic>Pregnancy</topic><topic>Protein Binding</topic><topic>Receptors, Virus - genetics</topic><topic>Receptors, Virus - metabolism</topic><topic>Renin-Angiotensin System - genetics</topic><topic>Review</topic><topic>SARS-CoV-2</topic><topic>Spike Glycoprotein, Coronavirus - genetics</topic><topic>Spike Glycoprotein, Coronavirus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jing, Yan</creatorcontrib><creatorcontrib>Run-Qian, Li</creatorcontrib><creatorcontrib>Hao-Ran, Wang</creatorcontrib><creatorcontrib>Hao-Ran, Chen</creatorcontrib><creatorcontrib>Ya-Bin, Liu</creatorcontrib><creatorcontrib>Yang, Gao</creatorcontrib><creatorcontrib>Fei, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jing, Yan</au><au>Run-Qian, Li</au><au>Hao-Ran, Wang</au><au>Hao-Ran, Chen</au><au>Ya-Bin, Liu</au><au>Yang, Gao</au><au>Fei, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential influence of COVID-19/ACE2 on the female reproductive system</atitle><jtitle>Molecular human reproduction</jtitle><addtitle>Mol Hum Reprod</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>26</volume><issue>6</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>1460-2407</issn><issn>1360-9947</issn><eissn>1460-2407</eissn><abstract>Abstract
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32365180</pmid><doi>10.1093/molehr/gaaa030</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2578-7159</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1460-2407 |
| ispartof | Molecular human reproduction, 2020-06, Vol.26 (6), p.367-373 |
| issn | 1460-2407 1360-9947 1460-2407 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7239105 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Angiotensin I - genetics Angiotensin I - metabolism Angiotensin II - genetics Angiotensin II - metabolism Angiotensin-Converting Enzyme 2 Betacoronavirus - pathogenicity Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronavirus Infections - pathology Coronavirus Infections - transmission COVID-19 Female Gene Expression Regulation Genitalia, Female - pathology Genitalia, Female - virology Host-Pathogen Interactions - genetics Humans Pandemics Peptide Fragments - genetics Peptide Fragments - metabolism Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - pathology Pneumonia, Viral - transmission Pregnancy Protein Binding Receptors, Virus - genetics Receptors, Virus - metabolism Renin-Angiotensin System - genetics Review SARS-CoV-2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism |
| title | Potential influence of COVID-19/ACE2 on the female reproductive system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T20%3A55%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20influence%20of%20COVID-19/ACE2%20on%20the%20female%20reproductive%20system&rft.jtitle=Molecular%20human%20reproduction&rft.au=Jing,%20Yan&rft.date=2020-06-01&rft.volume=26&rft.issue=6&rft.spage=367&rft.epage=373&rft.pages=367-373&rft.issn=1460-2407&rft.eissn=1460-2407&rft_id=info:doi/10.1093/molehr/gaaa030&rft_dat=%3Cproquest_pubme%3E2398617235%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2398617235&rft_id=info:pmid/32365180&rft_oup_id=10.1093/molehr/gaaa030&rfr_iscdi=true |