A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in terminating signals initiated by agonist-bound GPCRs. However, chronic stimulation of GPCRs, such as that which occurs during heart failure, leads to the overexpression of GRKs and maladaptive downregulation of GPCRs on the cell sur...

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Veröffentlicht in:	Molecular pharmacology 2020-06, Vol.97 (6), p.392-401
Hauptverfasser:	Bouley, Renee A., Weinberg, Zara Y., Waldschmidt, Helen V., Yen, Yu-Chen, Larsen, Scott D., Puthenveedu, Manojkumar A., Tesmer, John J.G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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