Tau affects P53 function and cell fate during the DNA damage response

Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shar...

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Veröffentlicht in:	Communications biology 2020-05, Vol.3 (1), p.245-245, Article 245
Hauptverfasser:	Sola, Martina, Magrin, Claudia, Pedrioli, Giona, Pinton, Sandra, Salvadè, Agnese, Papin, Stéphanie, Paganetti, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/51 14/19 38 38/1 631/378 631/80 692/699/375 692/699/375/365 82 82/29 Aging Biology Biomedical and Life Sciences Cancer Cell death Cell division Cell fate Deoxyribonucleic acid DNA DNA damage DNA repair Life Sciences MDM2 protein Neuroblastoma Neuroblasts Neurodegeneration Neurodegenerative diseases p53 Protein Senescence Tau protein Ubiquitin Ubiquitin-protein ligase
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