Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?
Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photos...
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| Veröffentlicht in: | Current opinion in chemical biology 2020-06, Vol.56, p.23-27 |
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| creator | McFarland, Sherri A. Mandel, Arkady Dumoulin-White, Roger Gasser, Gilles |
| description | Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity. |
| doi_str_mv | 10.1016/j.cbpa.2019.10.004 |
| format | Article |
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| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bacteriochlorophylls - chemistry Bacteriochlorophylls - pharmacology Bioinorganic chemistry Chemical Sciences Combined Modality Therapy Coordination Complexes - chemistry Coordination Complexes - pharmacology Drug Screening Assays, Antitumor Humans Medicinal inorganic chemistry Metals in medicine Neoplasms - therapy or physical chemistry Photochemotherapy Photodynamic therapy Photosensitizer Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Solubility Structure-Activity Relationship Theoretical and |
| title | Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology? |
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