Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain

In tribute to our friend and colleague Michael Robinson, we review his involvement in the identification, characterization and localization of the metallopeptidase glutamate carboxypeptidase II (GCPII), originally called NAALADase. While Mike was characterizing NAALADase in the brain, the protein wa...

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Veröffentlicht in:	Neurochemical research 2020-06, Vol.45 (6), p.1256-1267
Hauptverfasser:	Vornov, James J., Peters, Diane, Nedelcovych, Mike, Hollinger, Kristen, Rais, Rana, Slusher, Barbara S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Antigens Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Carboxypeptidase Castration Cell Biology Chemical compounds Clinical trials Drug development Drugs Enzymatic activity Enzymes FOLH1 gene Folic acid Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Gene expression Glutamate carboxypeptidase Glutamate Carboxypeptidase II - antagonists & inhibitors Glutamate Carboxypeptidase II - metabolism Humans Hydrolase Inflammatory bowel disease Inflammatory bowel diseases Inflammatory diseases Inhibitors Intestine Kidneys Ligands Localization Male Medical imaging Medical treatment Metalloproteinase Metastases Neurochemistry Neuroimaging Neurology Neurosciences Original Paper Positron emission Positron emission tomography Prodrugs Prodrugs - chemistry Prodrugs - pharmacology Prodrugs - therapeutic use Prostate - drug effects Prostate - metabolism Prostate cancer Radiation therapy Salivary gland Salivary glands Tomography Tumors
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