Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits

Abstract Context Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, t...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-05, Vol.105 (5), p.1401-1415
Hauptverfasser:	Aksit, Melis A, Pace, Rhonda G, Vecchio-Pagán, Briana, Ling, Hua, Rommens, Johanna M, Boelle, Pierre-Yves, Guillot, Loic, Raraigh, Karen S, Pugh, Elizabeth, Zhang, Peng, Strug, Lisa J, Drumm, Mitch L, Knowles, Michael R, Cutting, Garry R, Corvol, Harriet, Blackman, Scott M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amyloid Autoimmunity Beta cells Child Clinical Cohort Studies Complications and side effects Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - epidemiology Cystic Fibrosis - genetics Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Diabetes Mellitus - genetics Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female France - epidemiology Genes, Modifier Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic variation Genome-wide association studies Genome-Wide Association Study Genomes Humans Insulin Insulin secretion Life Sciences Male Polygenic inheritance Quantitative Trait, Heritable Risk Factors Type 1 diabetes Type 2 diabetes Young Adult
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