Comprehensive Assessment of Changes in Left Ventricular Diastolic Function With Contemporary Breast Cancer Therapy

This study determined the effects of doxorubicin and/or trastuzumab on diastolic function and the relationship between diastolic function and systolic dysfunction. Doxorubicin and trastuzumab can result in left ventricular ejection fraction (LVEF) declines. However, the effects of these therapies on...

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Veröffentlicht in:	JACC. Cardiovascular imaging 2020-01, Vol.13 (1), p.198-210
Hauptverfasser:	Upshaw, Jenica N., Finkelman, Brian, Hubbard, Rebecca A., Smith, Amanda M., Narayan, Hari K., Arndt, Linzi, Domchek, Susan, DeMichele, Angela, Fox, Kevin, Shah, Payal, Clark, Amy, Bradbury, Angela, Matro, Jennifer, Adusumalli, Srinath, Carver, Joseph R., Ky, Bonnie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult anthracyclines Antineoplastic Combined Chemotherapy Protocols - adverse effects Breast Neoplasms - drug therapy cardio-oncology Cardiotoxicity chemotherapy Diastole diastolic dysfunction Doxorubicin - adverse effects Echocardiography, Doppler Female Humans Longitudinal Studies Middle Aged Prospective Studies Risk Assessment Risk Factors Stroke Volume - drug effects Time Factors trastuzumab Trastuzumab - adverse effects Ventricular Dysfunction, Left - chemically induced Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - drug effects
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