Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase

Treatment of dengue virus (DENV) and other flavivirus infections is an unmet medical need. The highly conserved flaviviral NS5 RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target that interacts with NS3 and viral RNA within the replication complex assembly. Biochemical and cell-bas...

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Veröffentlicht in:	ACS medicinal chemistry letters 2020-05, Vol.11 (5), p.773-782
Hauptverfasser:	Cannalire, Rolando, Ki Chan, Kitti Wing, Burali, Maria Sole, Gwee, Chin Piaw, Wang, Sai, Astolfi, Andrea, Massari, Serena, Sabatini, Stefano, Tabarrini, Oriana, Mastrangelo, Eloise, Barreca, Maria Letizia, Cecchetti, Violetta, Vasudevan, Subhash G, Manfroni, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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