Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders
Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations during pregnancy and these alterations can influence fetal and neonatal phenotype which increase the risk of metabolic disorders in later stages of life. Objective: The effects of maternal obesity on fetal pr...
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| Veröffentlicht in: | Current genomics 2019-09, Vol.20 (6), p.419-427 |
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| creator | Şanlı, Ezgi Kabaran, Seray |
| description | Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations during pregnancy and these alterations can influence fetal and neonatal phenotype which increase the risk of metabolic disorders in later stages of life.
Objective: The effects of maternal obesity on fetal programming and potential mechanisms of maternal epigenetic regulation of gene expression which have persistent effects on fetal health and development were investigated.
Methods: Review of the literature was carried out in order to discuss the effects of maternal obesity and epigenetic mechanisms in fetal programming of metabolic disorders. All abstracts and full-text articles were examined and the most relevant articles were included in this review.
Results: Maternal obesity and maternal overnutrition during fetal period has important overall effects on long-term health. Maternal metabolic alterations during early stages of fetal development can lead to permanent changes in organ structures, cell numbers and metabolism. Epigenetic modifications (DNA methylation, histone modifications, microRNAs) play an important role in disease susceptibility in the later stages of human life. Maternal nutrition alter expression of hypothalamic genes which can increase fetal and neonatal energy intake. Epigenetic modifications may affect the increasing rate of obesity and other metabolic disorders worldwide since the impact of these changes can be passed through generations.
Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms. |
| doi_str_mv | 10.2174/1389202920666191030092225 |
| format | Article |
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Objective: The effects of maternal obesity on fetal programming and potential mechanisms of maternal epigenetic regulation of gene expression which have persistent effects on fetal health and development were investigated.
Methods: Review of the literature was carried out in order to discuss the effects of maternal obesity and epigenetic mechanisms in fetal programming of metabolic disorders. All abstracts and full-text articles were examined and the most relevant articles were included in this review.
Results: Maternal obesity and maternal overnutrition during fetal period has important overall effects on long-term health. Maternal metabolic alterations during early stages of fetal development can lead to permanent changes in organ structures, cell numbers and metabolism. Epigenetic modifications (DNA methylation, histone modifications, microRNAs) play an important role in disease susceptibility in the later stages of human life. Maternal nutrition alter expression of hypothalamic genes which can increase fetal and neonatal energy intake. Epigenetic modifications may affect the increasing rate of obesity and other metabolic disorders worldwide since the impact of these changes can be passed through generations.
Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms.</description><identifier>ISSN: 1389-2029</identifier><identifier>EISSN: 1875-5488</identifier><identifier>DOI: 10.2174/1389202920666191030092225</identifier><identifier>PMID: 32476999</identifier><language>eng</language><publisher>United Arab Emirates: Bentham Science Publishers Ltd</publisher><subject>Current Genomics ; Deoxyribonucleic acid ; Developmental stages ; Disorders ; DNA ; DNA methylation ; Energy intake ; Epigenetics ; Fetuses ; Gene expression ; Heredity ; Human nutrition ; Hypothalamus ; Literature reviews ; Metabolic disorders ; miRNA ; Neonates ; Nutrition ; Obesity ; Overnutrition ; Phenotypes ; Pregnancy ; Programming ; Weight control</subject><ispartof>Current genomics, 2019-09, Vol.20 (6), p.419-427</ispartof><rights>2019 Bentham Science Publishers.</rights><rights>Copyright Bentham Science Sep 2019</rights><rights>2019 Bentham Science Publishers 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b576t-b1df1c4531a1779a7a59573b3f4c98c85d72652c116a95ca4d0be5dd932a0dd03</citedby><cites>FETCH-LOGICAL-b576t-b1df1c4531a1779a7a59573b3f4c98c85d72652c116a95ca4d0be5dd932a0dd03</cites><orcidid>0000-0001-7022-4366 ; 0000-0002-1676-3606</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235386/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235386/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32476999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şanlı, Ezgi</creatorcontrib><creatorcontrib>Kabaran, Seray</creatorcontrib><title>Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders</title><title>Current genomics</title><addtitle>CG</addtitle><description>Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations during pregnancy and these alterations can influence fetal and neonatal phenotype which increase the risk of metabolic disorders in later stages of life.
Objective: The effects of maternal obesity on fetal programming and potential mechanisms of maternal epigenetic regulation of gene expression which have persistent effects on fetal health and development were investigated.
Methods: Review of the literature was carried out in order to discuss the effects of maternal obesity and epigenetic mechanisms in fetal programming of metabolic disorders. All abstracts and full-text articles were examined and the most relevant articles were included in this review.
Results: Maternal obesity and maternal overnutrition during fetal period has important overall effects on long-term health. Maternal metabolic alterations during early stages of fetal development can lead to permanent changes in organ structures, cell numbers and metabolism. Epigenetic modifications (DNA methylation, histone modifications, microRNAs) play an important role in disease susceptibility in the later stages of human life. Maternal nutrition alter expression of hypothalamic genes which can increase fetal and neonatal energy intake. Epigenetic modifications may affect the increasing rate of obesity and other metabolic disorders worldwide since the impact of these changes can be passed through generations.
Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms.</description><subject>Current Genomics</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental stages</subject><subject>Disorders</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Energy intake</subject><subject>Epigenetics</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Heredity</subject><subject>Human nutrition</subject><subject>Hypothalamus</subject><subject>Literature reviews</subject><subject>Metabolic disorders</subject><subject>miRNA</subject><subject>Neonates</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Overnutrition</subject><subject>Phenotypes</subject><subject>Pregnancy</subject><subject>Programming</subject><subject>Weight control</subject><issn>1389-2029</issn><issn>1875-5488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhiMEoqXwF1AQFw4s-COObQ5IqN0CUqtygLPlOJONS2KntrOr3jnxq3HYsnxIHKwZzTzzeuy3KJ5h9IpgXr3GVEiCSD51XWOJEUVIEkLYveIYC85WrBLifs4zt1rAo-JRjNcIESQ4elgcUVLxWkp5XHy_1AmC00N51UC06fZl-buyzXFOwSbrXaldW55DyvVPwW-CHkfrNm_KddeBSbH0Xbme7AYcJGvKSzC9djaOueHK1EN5BlsY_DSCSwt7mZUaP2T0zEYfWgjxcfGg00OEJ3fxpPhyvv58-mF1cfX-4-m7i1XDeJ1WDW47bCpGscacS801k4zThnaVkcII1nJSM2IwrrVkRlctaoC1raREo7ZF9KR4u9ed5maE1uSNgh7UFOyow63y2qq_O872auO3ihPKqKizwIs7geBvZohJjTYaGAbtwM9RkQoJVmFSL3c9_we99vPyuZmitKIci0pkSu4pE3yMAbrDMhipxXH1X8fz7NM_X3OY_GVxBr7tgSY_p9djNBacgQPYpzSp3W6nYA7wVUcYsp_K-FH5Cdwchpy7lGfV1E8qGxxA6ZBNHkDZGN3P3dSynNr6YR4h50tjBlWrOOkNqApL-gO1B9xM</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Şanlı, Ezgi</creator><creator>Kabaran, Seray</creator><general>Bentham Science Publishers Ltd</general><general>Benham Science Publishers</general><general>Bentham Science Publishers</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7022-4366</orcidid><orcidid>https://orcid.org/0000-0002-1676-3606</orcidid></search><sort><creationdate>20190901</creationdate><title>Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders</title><author>Şanlı, Ezgi ; Kabaran, Seray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b576t-b1df1c4531a1779a7a59573b3f4c98c85d72652c116a95ca4d0be5dd932a0dd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Current Genomics</topic><topic>Deoxyribonucleic acid</topic><topic>Developmental stages</topic><topic>Disorders</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Energy intake</topic><topic>Epigenetics</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Heredity</topic><topic>Human nutrition</topic><topic>Hypothalamus</topic><topic>Literature reviews</topic><topic>Metabolic disorders</topic><topic>miRNA</topic><topic>Neonates</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Overnutrition</topic><topic>Phenotypes</topic><topic>Pregnancy</topic><topic>Programming</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şanlı, Ezgi</creatorcontrib><creatorcontrib>Kabaran, Seray</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şanlı, Ezgi</au><au>Kabaran, Seray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders</atitle><jtitle>Current genomics</jtitle><addtitle>CG</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>20</volume><issue>6</issue><spage>419</spage><epage>427</epage><pages>419-427</pages><issn>1389-2029</issn><eissn>1875-5488</eissn><abstract>Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations during pregnancy and these alterations can influence fetal and neonatal phenotype which increase the risk of metabolic disorders in later stages of life.
Objective: The effects of maternal obesity on fetal programming and potential mechanisms of maternal epigenetic regulation of gene expression which have persistent effects on fetal health and development were investigated.
Methods: Review of the literature was carried out in order to discuss the effects of maternal obesity and epigenetic mechanisms in fetal programming of metabolic disorders. All abstracts and full-text articles were examined and the most relevant articles were included in this review.
Results: Maternal obesity and maternal overnutrition during fetal period has important overall effects on long-term health. Maternal metabolic alterations during early stages of fetal development can lead to permanent changes in organ structures, cell numbers and metabolism. Epigenetic modifications (DNA methylation, histone modifications, microRNAs) play an important role in disease susceptibility in the later stages of human life. Maternal nutrition alter expression of hypothalamic genes which can increase fetal and neonatal energy intake. Epigenetic modifications may affect the increasing rate of obesity and other metabolic disorders worldwide since the impact of these changes can be passed through generations.
Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms.</abstract><cop>United Arab Emirates</cop><pub>Bentham Science Publishers Ltd</pub><pmid>32476999</pmid><doi>10.2174/1389202920666191030092225</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7022-4366</orcidid><orcidid>https://orcid.org/0000-0002-1676-3606</orcidid><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Current Genomics Deoxyribonucleic acid Developmental stages Disorders DNA DNA methylation Energy intake Epigenetics Fetuses Gene expression Heredity Human nutrition Hypothalamus Literature reviews Metabolic disorders miRNA Neonates Nutrition Obesity Overnutrition Phenotypes Pregnancy Programming Weight control |
| title | Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders |
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