Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols
This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2 3 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture conten...
Gespeichert in:
| Veröffentlicht in: | AAPS PharmSciTech 2020-05, Vol.21 (5), p.143-143, Article 143 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 143 |
|---|---|
| container_issue | 5 |
| container_start_page | 143 |
| container_title | AAPS PharmSciTech |
| container_volume | 21 |
| creator | Bankole, Victor Oloruntoba Osungunna, Michael Oluwole Souza, Claudia Regina Fernandes Salvador, Sergio Luiz Oliveira, Wanderley Pereira |
| description | This work aims to improve the functionality of
Rosmarinus officinalis
L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2
3
Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (
X
p
); water activity (
A
w
); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH
•
) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with
X
p
and
A
w
of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC
50
of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against
Candida albicans
(ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties. |
| doi_str_mv | 10.1208/s12249-020-01668-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7235052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2404643866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-3649360615ab0eef8495dafa5cfa8bc03a9781ed4cc620e0d93543031b9b59df3</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2Fr9Ay4MSzdTDx_DHVyYmFrbJtfY-LEmDAO9NHNh5Mzc5P57qbc2deMKyPvycMJDyGsGp4xD9w4Z51I3wKEBplTX8CfkmLUCGq0Ff_pof0ReIN4CcMG0eE6OBJdcroAfk_h9KnbffCrRD_S65DFOGfPW43tqE71KKe_sHHeefvHzJg805ELPk7MTLmMNcqI50G8Zt7bEtGA9hehismNEuj6l13ncTxuf8ogvybNgR_Sv7tcT8vPz-Y-zy2b99eLq7OO6cVKquRFKaqFAsdb24H3opG4HG2zrgu16B8LqVcf8IJ1THDwMWrRSgGC97ls9BHFCPhy409Jv_eB8mosdzVRinXFvso3m3yTFjbnJO7PiooWWV8Dbe0DJvxaPs9lGdH4cbfJ5QcMlSCVFp1St8kPVlYxYfHh4hoG5c2QOjkx1ZP44Mnf8N48HfLjyV0otiEMBa5RufDG3eSn1T_F_2N_N4Z9f</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2404643866</pqid></control><display><type>article</type><title>Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols</title><source>SpringerLink Journals</source><creator>Bankole, Victor Oloruntoba ; Osungunna, Michael Oluwole ; Souza, Claudia Regina Fernandes ; Salvador, Sergio Luiz ; Oliveira, Wanderley Pereira</creator><creatorcontrib>Bankole, Victor Oloruntoba ; Osungunna, Michael Oluwole ; Souza, Claudia Regina Fernandes ; Salvador, Sergio Luiz ; Oliveira, Wanderley Pereira</creatorcontrib><description>This work aims to improve the functionality of
Rosmarinus officinalis
L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2
3
Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (
X
p
); water activity (
A
w
); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH
•
) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with
X
p
and
A
w
of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC
50
of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against
Candida albicans
(ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-020-01668-2</identifier><identifier>PMID: 32424702</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Pharmacology/Toxicology ; Pharmacy ; Research Article</subject><ispartof>AAPS PharmSciTech, 2020-05, Vol.21 (5), p.143-143, Article 143</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-3649360615ab0eef8495dafa5cfa8bc03a9781ed4cc620e0d93543031b9b59df3</citedby><cites>FETCH-LOGICAL-c446t-3649360615ab0eef8495dafa5cfa8bc03a9781ed4cc620e0d93543031b9b59df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1208/s12249-020-01668-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1208/s12249-020-01668-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32424702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bankole, Victor Oloruntoba</creatorcontrib><creatorcontrib>Osungunna, Michael Oluwole</creatorcontrib><creatorcontrib>Souza, Claudia Regina Fernandes</creatorcontrib><creatorcontrib>Salvador, Sergio Luiz</creatorcontrib><creatorcontrib>Oliveira, Wanderley Pereira</creatorcontrib><title>Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>This work aims to improve the functionality of
Rosmarinus officinalis
L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2
3
Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (
X
p
); water activity (
A
w
); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH
•
) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with
X
p
and
A
w
of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC
50
of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against
Candida albicans
(ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kU1vFSEUhonR2Fr9Ay4MSzdTDx_DHVyYmFrbJtfY-LEmDAO9NHNh5Mzc5P57qbc2deMKyPvycMJDyGsGp4xD9w4Z51I3wKEBplTX8CfkmLUCGq0Ff_pof0ReIN4CcMG0eE6OBJdcroAfk_h9KnbffCrRD_S65DFOGfPW43tqE71KKe_sHHeefvHzJg805ELPk7MTLmMNcqI50G8Zt7bEtGA9hehismNEuj6l13ncTxuf8ogvybNgR_Sv7tcT8vPz-Y-zy2b99eLq7OO6cVKquRFKaqFAsdb24H3opG4HG2zrgu16B8LqVcf8IJ1THDwMWrRSgGC97ls9BHFCPhy409Jv_eB8mosdzVRinXFvso3m3yTFjbnJO7PiooWWV8Dbe0DJvxaPs9lGdH4cbfJ5QcMlSCVFp1St8kPVlYxYfHh4hoG5c2QOjkx1ZP44Mnf8N48HfLjyV0otiEMBa5RufDG3eSn1T_F_2N_N4Z9f</recordid><startdate>20200518</startdate><enddate>20200518</enddate><creator>Bankole, Victor Oloruntoba</creator><creator>Osungunna, Michael Oluwole</creator><creator>Souza, Claudia Regina Fernandes</creator><creator>Salvador, Sergio Luiz</creator><creator>Oliveira, Wanderley Pereira</creator><general>Springer International Publishing</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200518</creationdate><title>Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols</title><author>Bankole, Victor Oloruntoba ; Osungunna, Michael Oluwole ; Souza, Claudia Regina Fernandes ; Salvador, Sergio Luiz ; Oliveira, Wanderley Pereira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-3649360615ab0eef8495dafa5cfa8bc03a9781ed4cc620e0d93543031b9b59df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bankole, Victor Oloruntoba</creatorcontrib><creatorcontrib>Osungunna, Michael Oluwole</creatorcontrib><creatorcontrib>Souza, Claudia Regina Fernandes</creatorcontrib><creatorcontrib>Salvador, Sergio Luiz</creatorcontrib><creatorcontrib>Oliveira, Wanderley Pereira</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AAPS PharmSciTech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bankole, Victor Oloruntoba</au><au>Osungunna, Michael Oluwole</au><au>Souza, Claudia Regina Fernandes</au><au>Salvador, Sergio Luiz</au><au>Oliveira, Wanderley Pereira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols</atitle><jtitle>AAPS PharmSciTech</jtitle><stitle>AAPS PharmSciTech</stitle><addtitle>AAPS PharmSciTech</addtitle><date>2020-05-18</date><risdate>2020</risdate><volume>21</volume><issue>5</issue><spage>143</spage><epage>143</epage><pages>143-143</pages><artnum>143</artnum><issn>1530-9932</issn><eissn>1530-9932</eissn><abstract>This work aims to improve the functionality of
Rosmarinus officinalis
L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2
3
Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (
X
p
); water activity (
A
w
); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH
•
) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with
X
p
and
A
w
of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC
50
of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against
Candida albicans
(ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32424702</pmid><doi>10.1208/s12249-020-01668-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-9932 |
| ispartof | AAPS PharmSciTech, 2020-05, Vol.21 (5), p.143-143, Article 143 |
| issn | 1530-9932 1530-9932 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7235052 |
| source | SpringerLink Journals |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Pharmacology/Toxicology Pharmacy Research Article |
| title | Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T09%3A36%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spray-Dried%20Proliposomes:%20an%20Innovative%20Method%20for%20Encapsulation%20of%20Rosmarinus%20officinalis%20L.%20Polyphenols&rft.jtitle=AAPS%20PharmSciTech&rft.au=Bankole,%20Victor%20Oloruntoba&rft.date=2020-05-18&rft.volume=21&rft.issue=5&rft.spage=143&rft.epage=143&rft.pages=143-143&rft.artnum=143&rft.issn=1530-9932&rft.eissn=1530-9932&rft_id=info:doi/10.1208/s12249-020-01668-2&rft_dat=%3Cproquest_pubme%3E2404643866%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2404643866&rft_id=info:pmid/32424702&rfr_iscdi=true |