Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

The overaccumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Accumulating evidence suggests that suppression of glycogen accumulation represents a potential therapeutic approach for treating these GSDs. Using...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	J. Med. Chem 2020-04, Vol.63 (7), p.3538-3551
Hauptverfasser:	Tang, Buyun, Frasinyuk, Mykhaylo S, Chikwana, Vimbai M, Mahalingan, Krishna K, Morgan, Cynthia A, Segvich, Dyann M, Bondarenko, Svitlana P, Mrug, Galyna P, Wyrebek, Przemyslaw, Watt, David S, DePaoli-Roach, Anna A, Roach, Peter J, Hurley, Thomas D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - enzymology Crystallography, X-Ray Drug Discovery Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Glycogen Synthase - antagonists & inhibitors Glycogen Synthase - chemistry Glycogen Synthase - metabolism HEK293 Cells Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - metabolism Kinetics Molecular Structure Protein Binding Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - metabolism Saccharomyces cerevisiae - enzymology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!