IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis
Within the spectrum of autoimmune liver diseases, there are patients who manifest features of more than one disease, which was previously identified as having overlap syndrome1,2 and is now referred to as variant syndromes. The most common variant syndrome is between primary biliary cholangitis (PBC...
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| Veröffentlicht in: | Clinical gastroenterology and hepatology 2021-02, Vol.19 (2), p.397-399 |
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| creator | Lee, Brian T. Wang, Yun Yang, Alexander Han, Hyosun Yuan, Liyun Donovan, John Kaplowitz, Neil Kanel, Gary Kahn, Jeffrey Dara, Lily |
| description | Within the spectrum of autoimmune liver diseases, there are patients who manifest features of more than one disease, which was previously identified as having overlap syndrome1,2 and is now referred to as variant syndromes. The most common variant syndrome is between primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Typically, AIH presents with elevated serum immunoglobulin (Ig) G, whereas PBC is associated with elevated serum IgM.3,4 Previous studies have suggested that plasma cells in liver biopsies of AIH patients are predominantly IgG+, whereas in PBC, there is an abundance of IgM+ cells.5,6 We wanted to determine the immunostaining pattern for IgG and IgM of liver plasma cells among Hispanic patients in Los Angeles with features of both PBC-AIH compared with those with PBC or AIH alone. |
| doi_str_mv | 10.1016/j.cgh.2019.11.024 |
| format | Article |
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The most common variant syndrome is between primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Typically, AIH presents with elevated serum immunoglobulin (Ig) G, whereas PBC is associated with elevated serum IgM.3,4 Previous studies have suggested that plasma cells in liver biopsies of AIH patients are predominantly IgG+, whereas in PBC, there is an abundance of IgM+ cells.5,6 We wanted to determine the immunostaining pattern for IgG and IgM of liver plasma cells among Hispanic patients in Los Angeles with features of both PBC-AIH compared with those with PBC or AIH alone.</description><identifier>ISSN: 1542-3565</identifier><identifier>EISSN: 1542-7714</identifier><identifier>DOI: 10.1016/j.cgh.2019.11.024</identifier><identifier>PMID: 31751773</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Hepatitis, Autoimmune - pathology ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Liver Cirrhosis, Biliary - pathology ; Phenotype ; Plasma Cells - pathology</subject><ispartof>Clinical gastroenterology and hepatology, 2021-02, Vol.19 (2), p.397-399</ispartof><rights>2021 AGA Institute</rights><rights>Copyright © 2021 AGA Institute. 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Typically, AIH presents with elevated serum immunoglobulin (Ig) G, whereas PBC is associated with elevated serum IgM.3,4 Previous studies have suggested that plasma cells in liver biopsies of AIH patients are predominantly IgG+, whereas in PBC, there is an abundance of IgM+ cells.5,6 We wanted to determine the immunostaining pattern for IgG and IgM of liver plasma cells among Hispanic patients in Los Angeles with features of both PBC-AIH compared with those with PBC or AIH alone.</description><subject>Hepatitis, Autoimmune - pathology</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Liver Cirrhosis, Biliary - pathology</subject><subject>Phenotype</subject><subject>Plasma Cells - pathology</subject><issn>1542-3565</issn><issn>1542-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1DAQjRAVLS0fwAX5yGVT24njDUhIZUXblRZRtSCO1sQ7SbxK4q3trNSv4JfrbbYVXDjNSPPem5n3kuQ9oymjrDjfpLppU05ZmTKWUp6_Sk6YyPlMSpa_PvSZKMRx8tb7DaW8zEv5JjnOmBRMyuwk-bNsrj4tm-_kFoKxntiarMwOHbnpwPdAFth1ntziDqEjd6Y3HcRZi4MND1t8wt8404N7IF9NZ_Z10doOhsYE48lvE1oCw_qpsWMglwhhdBPxYgzW9P04ILnGbdwfGWfJUQ2dx3eHepr8uvz2c3E9W_24Wi4uVjOdCxZmTFdIS8hA51BqpqEQFS041rzORC2jOXmOkvK5rmgtWAGaUZACKs2LAjnPTpMvk-52rHpcaxyCg05tp1-UBaP-nQymVY3dKcmzKC6iwMeDgLP3I_qgeuN1dAsGtKNXfO_xfB6PilA2QbWz3jusX9YwqvZBqo2KQap9kIoxFYOMnA9_3_fCeE4uAj5PAIwu7Qw65bXBQePaONRBra35j_wjLWKxOw</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Lee, Brian T.</creator><creator>Wang, Yun</creator><creator>Yang, Alexander</creator><creator>Han, Hyosun</creator><creator>Yuan, Liyun</creator><creator>Donovan, John</creator><creator>Kaplowitz, Neil</creator><creator>Kanel, Gary</creator><creator>Kahn, Jeffrey</creator><creator>Dara, Lily</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5975-5131</orcidid><orcidid>https://orcid.org/0000-0002-0121-7186</orcidid></search><sort><creationdate>20210201</creationdate><title>IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis</title><author>Lee, Brian T. ; 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The most common variant syndrome is between primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Typically, AIH presents with elevated serum immunoglobulin (Ig) G, whereas PBC is associated with elevated serum IgM.3,4 Previous studies have suggested that plasma cells in liver biopsies of AIH patients are predominantly IgG+, whereas in PBC, there is an abundance of IgM+ cells.5,6 We wanted to determine the immunostaining pattern for IgG and IgM of liver plasma cells among Hispanic patients in Los Angeles with features of both PBC-AIH compared with those with PBC or AIH alone.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31751773</pmid><doi>10.1016/j.cgh.2019.11.024</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0001-5975-5131</orcidid><orcidid>https://orcid.org/0000-0002-0121-7186</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Hepatitis, Autoimmune - pathology Humans Immunoglobulin G Immunoglobulin M Liver Cirrhosis, Biliary - pathology Phenotype Plasma Cells - pathology |
| title | IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis |
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