Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy

Neovascular retinal degenerative diseases are the leading causes of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) therapy is commonly used to treat these diseases currently. However, recent reports indicate that long term suppression of VEGF in the eye is associate...

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Veröffentlicht in:	Nutrients 2020-04, Vol.12 (4), p.1055
Hauptverfasser:	Shoda, Chiho, Miwa, Yukihiro, Nimura, Kazumi, Okamoto, Kazutoshi, Yamagami, Satoru, Tsubota, Kazuo, Kurihara, Toshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors Animal models Animals Antiangiogenic agents Antiangiogenics Atrophy Cytomegalovirus Developed countries Diabetes Diabetic retinopathy Disease Models, Animal Diseases Fatty acids Fishes - metabolism Genes Growth factors Homeostasis Hypoxia Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-inducible factors Ingredients Inhibitors Invasiveness Ischemia Kinases Laboratory animals Marine fish Mice, Inbred C57BL Monoclonal antibodies Oxygen - adverse effects Physiological effects Physiology Proteins Retina Retinal degeneration Retinal Neovascularization - drug therapy Retinal Neovascularization - etiology Retinopathy Tissue Extracts - isolation & purification Tissue Extracts - pharmacology Tissue Extracts - therapeutic use Vascular endothelial growth factor Vascularization
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