Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
Metastases to orofacial tissues are infrequent, their incidence being 1-8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, ging...
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| Veröffentlicht in: | Journal of clinical medicine 2020-04, Vol.9 (4), p.1151 |
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| creator | Capodiferro, Saverio Limongelli, Luisa Mastropasqua, Mauro Giuseppe Favia, Gianfranco Lajolo, Carlo Colella, Giuseppe Tempesta, Angela Maiorano, Eugenio |
| description | Metastases to orofacial tissues are infrequent, their incidence being 1-8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. In view of the necessity for prompt and accurate diagnosis of such unusual neoplasms, we report on the salient clinico-pathological features of 7 CCRCC metastatic to the oro-facial tissues, and highlight their immunohistochemical profile, to more accurately discriminate this neoplasm from other tumors of the oral cavity with a prominent clear cell component. |
| doi_str_mv | 10.3390/jcm9041151 |
| format | Article |
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Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. In view of the necessity for prompt and accurate diagnosis of such unusual neoplasms, we report on the salient clinico-pathological features of 7 CCRCC metastatic to the oro-facial tissues, and highlight their immunohistochemical profile, to more accurately discriminate this neoplasm from other tumors of the oral cavity with a prominent clear cell component.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9041151</identifier><identifier>PMID: 32316524</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antigens ; Bones ; Clinical medicine ; Cytokeratin ; Exocrine glands ; Kidney cancer ; Localization ; Lungs ; Metastasis ; Oral cancer ; Proteins ; Smooth muscle ; Thyroid gland ; Tumors</subject><ispartof>Journal of clinical medicine, 2020-04, Vol.9 (4), p.1151</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Antigens Bones Clinical medicine Cytokeratin Exocrine glands Kidney cancer Localization Lungs Metastasis Oral cancer Proteins Smooth muscle Thyroid gland Tumors |
| title | Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases |
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